血液灌流治疗重型肝炎临床研究  

A clinical study of hemoperfusion in treatment of severe hepatitis.

作　　者：张勇[1] 曾维政[1] 蒋明德[1] 熊碧君[1] 徐辉[1] 翁敏[1] 

机构地区：[1]成都军区总医院,四川成都610083

出　　处：《四川医学》2006年第3期259-261,共3页Sichuan Medical Journal

摘　　要：目的观察人血液灌流对重型肝炎的疗效。方法应用HA型血液灌流器对20例重型肝炎患者进行血液灌流36次。观察患者临床症状、肝、肾功能、电解质、凝血酶原活动度(PTa)、血氨、血常规及血清内毒素、肿瘤坏死因子α、白细胞介素6的变化。结果血液灌流后,患者临床症状均得到不同程度的改善。血清总胆红素、血氨较治疗前明显降低(P<0.01或P<0.05),内毒素、肿瘤坏死因子α、白细胞介素6明显降低(P<0.01),血小板减少(P<0.05)。不良反应较轻。结论血液灌流能吸附重型肝炎患者血液中胆红素、内毒素及细胞因子,是治疗重症肝炎的一种安全、有效的方法。Objective To investigate the therapeutic effect of hemoperfusion in severe hepatitis.Methods 20 patients with severe hepatitis were treated with HA hemoperfusion cartridge for 36 case-times. The result of liver function, renal function; electrolyte, prothrow.bin time activity, blood ammonla, blood routine, serum endotoxin （ET）, Tumor necrosis factor alpha （ TNF-α）, Interleukin-6 before and after the treatment were analyzed. Results After hemoperfusion, symptoms of patients with severe hepatitis were improved.Serum bilirubin, blood ammonia obviously reduced （ P 〈 0.05 or P 〈0. 01 ）, serum endotoxin, TNF-α w Interleukin-6 obviously reduced（ P 〈0. 01） .The side effects were mild. Conclusion Serum bilirubin, endotoxin, cytokines can be absorbed by hemoperfusion, hemoperfusion is comparatively safe and effective in the treatment of severe hepatitis.

关 键 词：人工肝 血液灌流 重症肝炎 内毒素 肿瘤坏死因子Α 

分 类 号：R512.6[医药卫生—内科学]