不同时期哮喘患儿血清白细胞介素-6变化的意义  

Significance of Serum Interleukin-6 in Attack or Stable Stage of Asthmatic Children

作　　者：温志红[1] 洪梅[1] 陶艳玲[1] 胡琼燕[1] 苏俐华[2] 

机构地区：[1]广西壮族自治区人民医院儿科,南宁530021 [2]广西壮族自治区人民医院核医学科,南宁530021

出　　处：《实用儿科临床杂志》2006年第4期214-215,共2页Journal of Applied Clinical Pediatrics

基　　金：广西壮族自治区科学基金项目资助(桂科青0447017)

摘　　要：目的探讨白细胞介素-6(IL-6)在支气管哮喘中的临床意义。方法采用放射免疫法检测29例哮喘急性发作期患儿、32例缓解期患儿血清IL-6水平,并设20例健康儿童为对照组。结果1.哮喘急性发作期患儿血清IL-6水平明显增高,与缓解期哮喘组及对照组比较,差异均非常显著(P均<0.001)。2.缓解期哮喘患儿IL-6水平仍高于正常对照组(P<0.001)。3.缓解期>3岁哮喘患儿IL-6水平较≤3岁组高(P<0.001)。结论IL-6参与哮喘的发病,在哮喘的各个时期发挥不同的生物学效应。Objective To explore the role and clinical significance of interleukin 6 （IL- 6） in children with bronchial asthma. Methods Sera were collected from 29 eases with 0sthmatic attacks, 32 asthmatic children who in stable conditions, and 20 health childrea.Serum IL - 6 concentrations were measured by radioimmunoassay （RIA）. Results 1. Asthmatic children appeared significantly higher levels of serum IL- 6 during asthmatic attacks as compared to those in stable conditions and healthy ones respectively （P 〈 0. 001 ）. 2. The serum IL - 6 concentrations in stable conditions were also markedly higher than that in control group （P〈0. 001 ）. 3. Asthmatic children〉3 years old had significantly higher serum IL - 6 concentrations than ≤3 years old children in remission. Conelusion IL -6 mav oarticioate oathogenesis of asthma, and it may olay different biological roles during asthmatic attacksas or stable conditions.

关 键 词：儿童 哮喘 白细胞介素-6 

分 类 号：R725.6[医药卫生—儿科]