抗癌丝裂霉素白蛋白微球的制备及体外释药性能  

Preparation and the Release Properties of Mitomycin Loaded Albumin Microspheres in Vitro

作　　者：陈锋[1] 李春忠[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

出　　处：《华东理工大学学报（自然科学版）》2006年第2期184-187,192,共5页Journal of East China University of Science and Technology

基　　金：上海市基础研究重大项目(04DZ14002);国家基础研究重大项目前期研究专项(2002CCA02200);国家自然科学基金(20236020;20176009);教育部重点项目(02159);上海市纳米科技基金项目等资助

摘　　要：以人血清白蛋白为载体材料,精制棉籽油为油相,采用乳化热固法制备了抗癌丝裂霉素C白蛋白微球,对丝裂霉素C白蛋白微球的粒径、载药量、包封率以及药物的体外释药等特性进行了研究。结果表明,采用乳化热固法制备的白蛋白微球平均粒径为500 nm;丝裂霉素C白蛋白微球的平均载药量为2.98μg/m g,包封率为61.2%,在体外具有明显的药物缓释效果。Mitomycin C albumin microspheres were prepared by emulsion-heat denaturation method using the natural macromolecule human serum albumin as core material and refined cottonseed oil as oil phase. Properties of mitomycin C albumin microspheres were investigated, including particle size, drug loading capacity, embedding ratio and drug sustained release property in vitro. The results show that the average size of spherical microspheres prepared by emulsion-heat denaturation method is about 500 nm; the average drug loading of mitomyein C albumin microspheres is about 2.98μg/mg and the sustained drug release effect is very obvious in vitro.

关 键 词：乳化热固法 白蛋白微球 丝裂霉素C 载药量 缓释 

分 类 号：TQ460.6[化学工程—制药化工]