基础卵泡刺激素水平和获卵数对IVF-ET结局的影响  

Impact of serum FSH level and the number of retrieved oocytes on clinical outcome of in vitro fertilization and embryo transfer

作　　者：赵静[1] 蔡霞[1] 胡泊[1] 史敏[1] 巴哈古丽.阿不拉 杜红[1] 玛依热.吐尔逊 

机构地区：[1]新疆医科大学第一附属医院生殖助孕室,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2006年第2期105-108,共4页Journal of Xinjiang Medical University

摘　　要：目的：探讨体外受精一胚胎移植（in vitro fertilization and embryo transfer，IVF-ET）过程中基础卵泡刺激素（FSH）水平及获卵数对IVF-ET结局的影响。方法：对180例不孕患者共180个IVF-ET周期的资料进行回顾性分析，比较不同FSH水平和不同获卵数患者年龄、受精率、卵裂率、优质胚胎率和临床妊娠率等指标的差异。结果：不同FSH水平患者年龄、促性腺激素（Gn）剂量、Gn促排时间、移植胚胎数、卵裂率、妊娠率经统计学检验，差异均无统计学意义（P〉0．05）。FSH：〉8．78IU／L者获卵数明显低于FSH〈3．85IU／L和FSH3．85～8．78IU／L组（P〈0．05），而受精率和优质胚胎率却明显高于其它2组（P〈0．05）。随年龄增长、FSH水平增加获卵数逐渐减少，差异有统计学意义（P〈0．05）；不同获卵数者的受精率、卵裂率、优质胚胎率、临床妊娠率及中重度卵巢过度刺激综合征（OHSS）发生率，差异均有统计学意义（P〈0．05），获卵数≤5个受精率最高，获卵数〉15个受精率最低；获卵数6～15个卵裂率、优质胚胎率最高；随着获卵数的增加，临床妊娠率和中重度OHSS发生率也逐渐增高。获卵数和FSH水平呈显著性负相关（r=-0．246，P〈0．01）；经多因素Logistic回归分析，年龄、获卵数、移植胚胎数与IVF-ET妊娠结局具有相关性（P〈0．05）。结论：基础FSH水平不能预测IVF-ET的临床结局，而获卵数可以预测IVFET临床结局。Objection： To evaluate the impact of basic serum follicle stimulating hormone （FSH） level and the number of retrieved oocytes on clinical outcome of in vitro fertilization and embryo transfer（IVF-ET）. Methods： One hundred and eighty cycles of IVF-ET were analyzed retrospectively. Compared the age, fertilization rate, cleavage oocytes rate, advanced embryos rate and pregnancy rate by different FSH level and the number of retrieved oocytes. Results： The age, gonadotropin doses, gonadotropin days, cleavage oocytes rate, pregnancy rate and number of transferred embryos by different FSH level had no statistical significance （P 〉0.05） ; In FSH〉8.78 IU/L group the number of retrieved oocytes have more than that in other groups （P 〈0.05）, while fertilization rate and advanced embryos had less than that in other groups （P 〈0.05）. The number of retrieved oocytes were decreased with the gain of patient＇s age and rise of the FSH level. The fertilization rate, cleavage oocytes rate, advanced embryoh rate, pregnancy rate and OHSS rate had statistical significance （P 〈0.05） by different the number of retrieved oocytes . The fertilization rate was the highest in the number of retrieved oocytes ≤5 group and lowest in the number of retrieved oocytes〉15 group. The cleavage oocytes rate and advanced embryos rate were both highest in the number of retrieved oocytes 6～15 group. The pregnancy rate and OHSS rate were increased with the increase of the number of retrieved oocytes. The FSH level and the number of retrieved oocytes were negative correlations （r =- 0. 246, P 〈0.01）. There were significance of age, number of retrieved oocytes and transferred embryos on clinical pregnancy were found when the multiple-variate logistic regression analysis was used. Conclusion. Basic serum FSH level can not predict outcome of IVF ET, but number of retrieved oocytes can do.

关 键 词：体外受精-胚胎移植 卵 妊娠率 

分 类 号：R715.2[医药卫生—妇产科学] R715.9[医药卫生—临床医学]