心理应激因素在系统性硬化病发病中的作用(英文)  

Effect of psychological stress factors in the attack of systemic sclerosis

作　　者：陈跃[1] 黄继宗 章巧云[1] 周飞雪[1] 乔晓芝[1] 强裕 郭国侠 

机构地区：[1]浙江大学医学院附属第一医院城站院区老年病科,浙江省杭州市310009 [2]杭州同济医院外科,浙江省杭州市310012

出　　处：《中国临床康复》2006年第6期162-164,共3页Chinese Journal of Clinical Rehabilitation

基　　金：上海铁路局科学技术基金资助项目(B340406052)~~

摘　　要：背景:系统性硬化病的确切机制尚不清楚,临床发现该病发病前往往有形式不同的心理应激因素存在。目的:对系统性硬化病患者进行深入的心理社会因素调查,对比中国常模和对照组,结合临床免疫学检测,初步分析心理应激因素所起的作用。设计:对照观察。单位:浙江大学医学院第一医院城站院区老年病科和杭州同济医院外科对象:选择2002-12/2005-09在浙江大学医学院第一医院城站院区内科病区接受胸导管淋巴液引流疗法治疗的系统性硬化病住院患者26例为观察对象(系统性硬化病组)。对照组来自同病区同时期的慢性胃炎住院患者30例。方法:所有参加者均填写一般情况调查表。内容包括:年龄、性别、主要症状、病程、特殊检查、诊断和药物治疗。采用心理社会量表评定心理社会因素。采用生活事件量表测评生活事件应激,包括职业、学习、婚姻和恋爱、家庭和子女、经济、司法、人际关系等方面常见的生活事件;采用简易应对方式问卷评定应对方式,分为8个主成分:对抗、淡化、自控、求助、自责、逃避、计划和再评,将习惯性应对方式分为消极和积极两类。采用艾森克个性问卷评定人格特征,4个分量表组成,为外向-内向量表、神经质量表、精神质量表和掩饰、假托量表。同时取患者空腹血3mL采用免疫比浊法测定血清lgG、lgA、lgM和补体C3。并对lgG与其他因素进行相关分析。主要观察指标:心理社会量表评定结果及临床免疫学检测结果。结果:56例患者均完成量表测评和免疫学检测,全部进入结果分析。系统性硬化病组患者生活事件量表评定中,生活事件发生的总件数、负性事件数和负性事件LEU值均显著大于对照组。应对方式中,积极应对维度少于对照组,消极应对维度多于对照组。艾森克个性问卷评定中,无论男女外向-内向因子分均小于对照组及常模�BACKGROUND： The real mechanism of systemic sclerosis is still not clear, it is found clinically that there are psychological stress factors of different forms before the attack. OBJECTIVE： To deeply investigate the psychosocial factors in patients with systemic sclerosis, and primarily analyze the role of psychological stress factors by comparing with national norms and controls as well as combining with clinical immunological test. DESIGN： A controlled observation SESIGN： The experiments were carried out in the Department of Getiattics, the First Hospital Affiliated to Medical College, Zhejiang University and the Department of Surgery, Hangzhou Tongji Hospital. PARTICIPANTS： Between December 2002 and September 2005, 26 patients with systemic sclerosis （systemic sclerosis group）, who received thoracic duct lymph drainage therapy, and 30 inpatients with chronic gastritis （control group） were selected from the same disease area of the Department of Internal Medicine, the First Hospital of Medical CoUege, Zhejiang Uni- versity. METHODS： All the patients filled the general information inventory, the contents included were age, gender, main symptoms, disease course, special examination, diagnosis and drug therapy. The psychosocial scale was used to evaluate the psychosocial factors. Life event scale （LES） was used to assess the life events stress, including profession, learning, marriage and love, family and child, economics, justice, interpersonal relationship and other common life events. The simplified coping style questionnaire （SCSQ） was applied to assess the coping styles, including 8 main components： confrontation, indifference, self-control, seeking help, self-blame, escape, planning and roassessment, and then the habitual coping styles were divided into negative ones and positive ones. The Eysenck personality questionnaire （EPQ） was used to evaluate the personality characters, it consisted of 4 subscales： extraversion-introversion scale, neuroticism scale, psychoticism scal

关 键 词：应激 心理学 监测 免疫学 硬化病 成人 

分 类 号：R395.1[哲学宗教—心理学]