溶胶-凝胶法制备磷灰石-硅灰石多孔生物活性玻璃陶瓷的生物活性(英文)  

Bioactivity of sol-gel derived apatite/wollastonite porous bioactive glass-ceramic

作　　者：杨为中[1] 周成昕[1] 肖斌[1] 尹光福[1] 周大利[1] 

机构地区：[1]四川大学材料科学与工程学院,四川省成都市610064

出　　处：《中国临床康复》2006年第9期185-187,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家"八六三"高技术计划(2002AA326080);教育部优秀青年教师基金(2002123)资助~~

摘　　要：背景:磷灰石-硅灰石玻璃陶瓷是生物活性优异的骨修复材料,一般通过高温熔制法制备。目的:观察新型溶胶-凝胶法制备磷灰石-硅灰石生物活性玻璃陶瓷及其生物活性。设计:材料工艺设计实验,活体外生物活性实验。单位:四川大学材料科学与工程学院。材料:磷灰石-硅灰石玻璃陶瓷。方法:实验于2002-08/2003-05在四川大学材料科学与工程学院生物材料研究实验室完成。采用溶胶-凝胶法及后续热处理工艺制备磷灰石-硅灰石玻璃陶瓷,试样在模拟体液中于37℃浸泡7d,通过观察表面磷灰石的形成情况考察材料的生物活性。采用JL-1155型激光粒度仪、X射线衍射仪、傅立叶红外转换光谱仪、扫描电子显微镜进行表征分析。主要观察指标:①新工艺溶胶-凝胶法制备的玻璃陶瓷材料的晶型结构、显微结构。②模拟体液中材料表面磷灰石形成情况。③多孔型溶胶-凝胶硅灰石/磷灰石玻璃陶瓷孔径。结果:①溶胶-凝胶工艺制备出玻璃陶瓷材料,其主晶相为羟基磷灰石、氟磷灰石和β-硅灰石,微观结构包括大量2.0～3.0μm微孔。②溶胶-凝胶磷灰石-硅灰石玻璃陶瓷生物活性优异:体外模拟体液浸泡7d后,表面生成大量磷灰石颗粒。③多孔支架材料孔隙形态优异,为300～400μm直径相互贯通的大孔结构。结论:通过溶胶-凝胶工艺制备了具有优异生物活性的磷灰石-硅灰石玻璃陶瓷;此材料可望成为优异的骨修复材料及骨组织工程支架材料。BACKGROUND： Apatite-wollastonite containing glass-ceramic （AWGC） is a kind of good bone repairing materials with excellent bioactivity, which is prepared by traditional melting process. OBJECTIVE： To observe AWGC prepared with sol-gel method and its bioactivity. DESIGN： Design experiment of materials process and in vitro bioactivity experiment： SETTING： College of materials science and Engineering ofSichuan University. MATERIALS： AWGC. METHODS： This experiment was conducted at the laboratory of College of Materials Science and Engineering of Sichuan University between August 2002 and May 2003. AWGC was prepared from sol-gel and folio.wed by heattreating process.. Bioactivity was investigated in vitro by immersing in the simulate body fluid （SBF） at 37℃ for 7 days . JL-1155 laser particle ana- lyzer, X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscope were used for micro-morphological structure analysis. MAIN OUTCOME MEASURES： ①The crystalline structure and microstructure of sol-gel derived glass-ceramic②The apatite forming process in simulate body fluid③ The diameter of the pore of the sol-gel derived apatite/woliastonite glass-ceramic RFSULTS： ①Main crystalline phases of the sol-gel derived glass-ceramlc materials were hydroxyapatite/fluoroapatite [Ca10（PO4）6（OH, F）] and β-wollastonite[β-CaSiO3]; Microstructure contained many micro-pores of 2-3μm; ② Sol-gel derived AW glass ceramic had excellent bioactivity： plenty of apatite granules were generated on the surface of the material after soaking for 7 days. ③Porous scaffolds possessed good macro-perous structure with the interconnected macro pores of 300-400μm in diameter;, CONCLUSION： Apatite-wollastonite containing glass-ceramic （AWGC） with excellent hioactivity was developed by sol-gel process. The material is expected to be a good candidate for bone-repalring and bone tissue engineering scaffold materials.

关 键 词：组织工程 陶瓷制品 材料试验 磷灰石 硅 玻璃 

分 类 号：R318.08[医药卫生—生物医学工程]