半肝交替三维立体定向适形非常规分割照射对狗肝脏损伤与修复的实验研究  

An experimental study of dog liver injury and recovery after semi-liver alternate three - dimensional conformal and unconventional division radiotherapy.

作　　者：滑波[1] 梁军[1] 史恒军[1] 邵秋菊[1] 周慧敏[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《现代肿瘤医学》2006年第3期270-272,共3页Journal of Modern Oncology

摘　　要：目的 探索狗半肝交替三维立体定向非常规分割照射后放射损伤和修复的变化及其时间与剂量效应的关系。方法 随机将20只狗分成4组：A组3．0Gy×（8＋8）f、B组3．5Gy×（8＋8）f、12组4．0Gy×（8＋8）f、D组为对照组，观察照射后1、2周及1、3、6个月的组织形态学变化及照射后不同时间的肝脏放射毒性反应。结果 3个不同剂量组照射后不同时间全血计数、TP、GPT、AKP、TbiL、CHE与照射前比较无显著差异（P〉0．05），照射后1～2周可见急性放射性肝炎改变；1～3月可见肝脏损伤性改变；3～6个月A组肝脏损伤轻微，C组可见迟发性肝损伤恢复性改变。结论 在4．0Gy×（8＋8）f以内半肝交替照射对肝脏无毒性反应；随着放射剂量加大肝损伤加重，照射后6个月：A组肝损伤基本恢复，C组出现典型的放射性肝纤维化改变。Objective To explore the change of dog＇s liver after semi - fiver alternate and three - dimensional conformal unconventional division radiotherapy . Methods Twenty dog were randomly divided into 4 groups,including the A.B、C and D group. The group A, B, and C were separately treated with 3.0Gy × （8 ＋8）f , 3.5Gy × （8 ＋ 8 ） f、4.0Gy × （8 ＋ 8 ） f, group D was control group of normal dog,to observe the change of tissue morphologic and the toxicity reaction of liver after irradiation in different time of 1,2 week and 1,3, 6 month . Results The 3 different dosage groups were no marked difference with themselves before irradiation on whole blood, TP, GPT, AKP, TbiL, CHE （P 〉 0.05 ） , there were urgent radioactive hepatitis after irradiation 1 -2 weeks and liver damnify after 1 -3 months; there were gently damnify in the group A and late resume change of liver in goup C . Conclusion There were are no toxicity reaction of liver below 4.0Gy × （ 8 ＋ 8 ） f when treated with semi - liver alternate and three - dimensional conformal and radiotherapy; but liver damnify is aggravated with the radiatd dosage enlarged. After irradiation 6 months,liver damage of group A has been recovered,classic irradiation liver fibrosis has appeared in group C.

关 键 词：肝脏 放射损伤 三维立体定向适形放射治疗 半肝交替 动物实验 

分 类 号：R454[医药卫生—治疗学] R730.55[医药卫生—临床医学]