培哚普利及伊贝沙坦联合治疗对原发性高血压左室肥厚的逆转作用  

Effect of Progress Combined with Irbesartan on Reversing Left Ventricular Hypertrophy in Patients with Essential Hypertension

作　　者：黄仕洲[1] 刘明[1] 

机构地区：[1]广东省肇庆市第一人民医院心内科,肇庆526021

出　　处：《热带医学杂志》2006年第2期174-175,182,共3页Journal of Tropical Medicine

摘　　要：目的探讨培哚普利、伊贝沙坦、两者联合用药对原发性高血压(EH)患者左室肥厚(LVH)的干预作用。方法EH伴有LVH患者112例随机分成A组(培哚普利4mg/d37例)、B组(伊贝沙坦150mg/d,38例)和C组(培哚普利4mg/d37例,加伊贝沙坦150mg/d)。治疗3周时若血压≥160/95mmHg(1mmHg=0.133kPa),则培哚普利和伊贝沙坦剂量分别增加至8mg/d和300mg/d。总疗程共6个月,治疗前后彩色超声多普勒检测左室相关数据,计算左室重量指数(LVMI)和行24h动态血压监测。结果①3组治疗前后比较均能显著降低LVMI(P<0.01)。其中A组和B组LVMI的降低差异无显著意义(P>0.05),但C组LVMI降低较A组、B组两组更为显著,差异具有显著性意义(P<0.01)。②分别比较3组治疗前24h平均收缩压、平均舒张压差异无显著性意义(P>0.05),治疗后24h平均收缩压、平均舒张压均分别较治疗前显著降低(P<0.01),但治疗后3组间比较均无明显差别(P>0.05)。结论培哚普利、伊贝沙坦均能逆转EH患者LVH,培哚普利和伊贝沙坦联合用药疗效更为显著,这种协同作用与降压效应无关。Objective To examine the effects of progress and irbesartan used individually or in combination on reversing left ventricular hypertrophy（LVH） in patient with essential hypertension（EH）. Methods 112 patients with EH were divided randomly into three groups： progress（progress 4 rag qd, n=37）, irbesartan （irbesartan 150 mg qd,n=38）, and combined treatment （progress 4 mg＋irbesartan 150 mg qd,n=37）. If BP≥（160/95）mmHg was remained after 3 weeks treatment, then the dose was doubled. Treatment was lasted for 6 months. LVMI was measured by heart Doppler ultra-sound before and after treatment. The blood pressure was recorded by ABPM at the same time. Results ①After 6 months, LVMI was significantly less than that before treatment in all the three groups （P〈0.01）. LIVI in the combined treatment group was less than that in the irbesartan and progress groups （P〈0.01）. No significant difference was found between progress and irbesartan groups （P〉0.05）. ②Before treatment and after 6 months of treatment, there was no significant difference in 24 h SBP and 24 h DBP among all three groups （P〉 0.05）. Conclusion Progress combined with irbesartan has additive effect on reversing LVH in patients with EH, and this additive effect is not related with decreasing blood pressure.

关 键 词：高血压 左心室肥厚 培哚普利 伊贝沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]