川芎丹皮合剂对微循环的影响  

Effects of Chuanxiongdanpi Mixture on Microcirculation

作　　者：邢国庆[1] 邢东生 乔现福[1] 邱玉芳[1] 

机构地区：[1]泰山医学院机能学实验室,山东泰安271000 [2]肥城市人民医院,山东肥城271600

出　　处：《泰山医学院学报》2005年第5期408-410,共3页Journal of Taishan Medical College

摘　　要：目的观察活血化瘀药川芎丹皮合剂对微循环的作用。方法①采用小鼠耳廓微循环观测法观察川芎丹皮合剂对小鼠耳廓血管血流速度、流量的作用;②用大鼠肠系膜微循环观测法,观察川芎丹皮合剂对大鼠肠系膜微循环的作用。结果川芎丹皮合剂4．3 g·kg-1和2．15 g·kg-1给小鼠灌胃后,增加耳廓血流量、提高血流速度。川芎丹皮合剂1．5 g·kg-1、3．0g·kg-1组的大鼠注射羊水前后肠系膜微循环无明显差异(P>0．05),川芎丹皮合剂组与对照组比较有显著性差异(P<0．05,P<0．01)。结论川芎丹皮合剂能明显改善微循环,提高耐缺氧能力。Objective： To observe the effects of Chuanxiongdanpi Mixture （CDM） on microcirculation in rats and mice. Methods： Velocity and flux of auricle blood flow were observed in mice. Meanwhile mesenteric microcirculation was assesed in rats. Results： 4.3 g·kg^-1and 2.15 g·kg^-1CDM in mice augmented the velocity and flux of auricle blood flow. As in rats, two CDM groups （ 1.5 g·kg^-1 and 3.0 g·kg^-1） showed significant effects compared to control group （ P 〈 0.05, P 〈 0.01 ）, with no significant difference in mesenteric microcirculation before and after injection of amniotic fluid （ P 2〉0.05）. Conclusion： CDM can improve perfusion of mierocirculation and enforce the ability of anti- hypoxia.

关 键 词：川芎丹皮合剂 微循环 羊水 肠系膜 

分 类 号：R285[医药卫生—中药学]