儿童血浆瘦素水平与肥胖度的关系  

The Relationship between Plasma Leptin Concentration and Adiposity in Children

作　　者：李英[1] 张新洁[1] 姜蕊[1] 李扬[1] 康颖[1] 王凤荣[1] 胡天一[1] 王金良[1] 

机构地区：[1]天津市公安医院,300050

出　　处：《天津医药》2006年第1期18-19,共2页Tianjin Medical Journal

摘　　要：目的:研究9～12岁儿童血浆瘦素(leptin)水平与体脂和性别的关系。方法:用酶联免疫分析法(ELISA)测定30例正常体质量儿童(正常组)和53例肥胖儿童(肥胖组)的血浆瘦素水平。结果:正常组瘦素浓度男童为(1.44±1.22)μg/L,女童为(2.30±1.53)μg/L;体质量指数(BMI)男童为(16.61±1.22)kg/m2,女童为(15.16±1.68)kg/m2。肥胖组瘦素浓度男童为(15.05±7.97)μg/L,女童为(16.15±7.67)μg/L,BMI男童为(25.28±2.76)kg/m2,女童为(23.26±2.63)kg/m2。血浆瘦素水平与BMI呈正相关(男童r=0.76,女童r=0.87,P<0.05)。少数(5.7%)肥胖儿童具有瘦素相对性缺乏。结论:大多数肥胖儿童存在瘦素抵抗,少数为瘦素相对性缺乏的肥胖儿将成为瘦素治疗的对象。Objective： To investigate the relationship between plasma leptin concentration and body fat, gender in children from nine to twelve years old. Methods： The plasma leptin concentration was measured by ELISA in thirty healthy （the control group） and fifty-three obese（the obese group）children. Results： The plasma leptin concentration in healthy children was （1.44 ± 1.22）μg/L in male and （2.30 ± 1.53）μg/L in female, while they were （15.05 ± 7.97）μg/L in male and （16.15 ± 7.67）μg/L in female in the obese group respectively,there was a little higher in female than that of male. The BMI in healthy children was （16.61±1.22） kg/m^2 in male and （15.16±1.68）kg/m^2 in female, while in obese children they were （25.28 ± 2.76）kg/m^2 in male and （23.26 ± 2.63）kg/m^2 in female respectively. Most leptin levels were positively correlated with BMI（r = 0.76, P 〈 0.05 in male; r = 0.87, P 〈 0.05 in female）.A little part （5.7%） of obese children had a comparative deficiency of leptin. Conclusion： Most obese children are resistant to leptin, only few of them who are comparatively deficient of leptin may become the good candidates for leptin treating in future.

关 键 词：瘦素 肥胖症 儿童 人体质量指数 

分 类 号：R714.246[医药卫生—妇产科学] R725.892[医药卫生—临床医学]