酶中组氨酸残基与水分子间的氢迁移及氧化对其影响  

THE HYDROGEN TRANSFER BETWEEN WATER AND THE RESIDUES OF HISTIDINE IN ENZYME AND AFFECTED BY OXIDATION

作　　者：李国清 崔瑞海 范卓文 

机构地区：[1]哈尔滨师范专科学校,黑龙江省中医学院

出　　处：《哈尔滨师范大学自然科学学报》1996年第1期65-66,共2页Natural Science Journal of Harbin Normal University

摘　　要：采用量子化学的ＣＮＤＯ／２法，探讨了酶活性部位的组氨酸残基和水之间氢键的形成和氢迁移问题，对组氨酸残基被氧化前后的氢健构成和催化机理进行了比较，为研究酶催化过程提供了有益的信息。In this paper,we approach the formation of hydrogen bond and the problem of hydrogen transfer between water and the enzyme active position of histidine residues by CNDO/2 method of quantum chemistry, compare the constitution of hydrogen bond and catalysis mechanism,oxidated the residues of histidine from beginning to end;supply studing of enzyme catalysis with useful information.

关 键 词：酶 组氨酸 氢迁移 水分子 氧化 催化活性 

分 类 号：Q55[生物学—生物化学]