固冲止血汤治疗无排卵型功能失调性子宫出血的临床观察  

Clinical Study of Guchong Zhixue Decoction in Treating Dysfunctional Uterine Bleeding of Anovulatory Type

作　　者：刘金星[1] 

机构地区：[1]山东中医药大学附属医院,济南250011

出　　处：《中国中西医结合杂志》2006年第2期159-162,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察固冲止血汤治疗气虚血瘀型无排卵型功能失调性子宫出血(简称功血)出血期的疗效并对其止血机理进行探讨。方法将60例气虚血瘀型功血患者随机分为治疗组(30例,口服固冲止血汤)及对照组(30例,口服益宫止血口服液),观察两组止血疗效、治疗前后临床症状改善情况、子宫内膜厚度、凝血酶原时间及部分凝血活酶时间、血清Ca2+水平、内分泌激素、经血血清前列腺素E2(PGE2)及前列腺素F2α(PGF2α)、子宫内膜雌激素受体(ER)、孕激素受体(PR)含量等变化。结果固冲止血汤治疗止血疗效总有效率为93.3%,显著优于对照组(70.0%,P<0.05)。治疗组治疗后在改善临床症状、子宫内膜厚度、凝血酶原时间及部分凝血活酶时间、血清Ca2+水平、经血血清PGE2及PGF2α、子宫内膜ER、PR含量等方面,与治疗前比较差异均有显著性(P<0.05,P<0.01);与对照组治疗后比较差异亦有显著性(P<0.05)。结论固冲止血汤对于气虚血瘀型功血出血具有良好的止血作用,并能显著改善伴随症状。Objective To observe the efficacy of Guchong Zhixue Decoction （GCZXD） in treating dysfunctional uterine bleeding of anovulatory type with Qi-deficiency and blood stasis syndrome, and to systematically explore its hemostasis mechanism, Methods Sixty patients were randomly divided into the treated group （n = 30, treated by GCZXD taken orally） and the control group （ n = 30, treated by Yigong Zhixue Oral Liquid, taken orally）. Hemostatic effect of treatment, improvements of clinical symptoms, thickness of endometrium, prothrombin time （PT） and activated partial prothrombin time （APTT）, serum level of Ca^2＋ , endocrine hormone, levels of PGE2 and PGF2α in menstrual blood serum, and contents of endometrial estrogen receptor （ER） and progestin receptor （PR） before and after treatment were observed. Results The total effective rate of GCZXD in hemostasis was 93.3% in the treated group, which was significantly better than that in the control group （70.0 %, P 〈 0.05）. Significant difference was shown in improving clinical symptoms, thickness of endometriurn, PT and APTT, serum level of Ca^2＋ , endocrine hormone, levels of PGE2 and PGF2α in menstrual blood serum, and contents of endometrial ER and PR in the treated group when compared with before treatment （P 〈 0.05, P〈0.01） also when compared with the control group after treatment （P〈0.05）. Conclusion GCZXD has favorable hemostatic effect in treating dysfunctional uterine bleeding of Qi deficiency and blood stasis syndrome, and it also con improve the accompanied symptoms significantly.

关 键 词：固冲止血汤 气虚血瘀 功能失调性子宫出血 凝血酶原时间 前列腺素F2Α 雌激素受体 

分 类 号：R271.9[医药卫生—中西医结合]