高尿酸血症与心血管事件的相关性探讨  

Research on the relationship between hyperuricemia and cardiovascular events

作　　者：兰庆萍[1] 张朝明[1] 谢文[2] 

机构地区：[1]成都中医药大学附属医院检验科,四川成都610072 [2]成都中医药大学附属医院心血管内科,四川成都610072

出　　处：《现代医药卫生》2006年第5期639-640,共2页Journal of Modern Medicine & Health

摘　　要：目的:分析探讨高尿酸血症与心血管事件之间的关系。方法:采用酶法在日立7170全自动生化分析仪上测定冠心病组(CHD)、高血压组(HBP)和正常对照组血尿酸(UA)、血糖(Bs)和血脂包括胆固醇(TC)、甘油三酯(TG)及高/低密度脂蛋白(HDL-C/LDL-C)水平。并加以分析比较。结果:CHD组、HBP组血尿酸水平比对照组有明显升高(P<0.01)。同时在冠心病组中进行的各指标之间的相关分析显示:尿酸升高与GLU、TG呈显著正相关(P<0.05),与其他三项无显著性相关。结论:在代谢异常的个体中,高尿酸血症与多种危险因素(如高血压,糖尿病,高血脂等)伴随,影响着心血管事件的发生和发展。故而尿酸有可能成为预测心血管疾病的又一个指标。Objective ：To analyze and investigate the relationship between hyperuricemia and cardiovascular events. Methods： In this investigation, the serum uric acid, serum glucose and Serum Lipid （TC,TG,HDL-C,LDL-C） in CAD group,HBP group and control group were measured with enzymatic colofimetry by biochemical autoanalyzer, and were compared with each other. Results：The level of serum uric acid was significantly higher in CAB group and HBP group than in control group（P〈0.01）. The relationship of indexes in CAD group was analyzed, there was a significant positive correlativity among levels of UA and Bs,UA and TG（P〈0.05）, no eorrelativity levels of UA and others （P〉0.05）. Conclusion：Hyperuricemia associated with other risk factors （diabetes, hypertension, and Hypolipidemic etc.） in a metabolic disorder individual, which can influence occurrence and development of cardiovascular events. So it is very possible that serum uric acid will be another predictive index of coronary heart disease.

关 键 词：高尿酸血症 心血管事件 危险因素 

分 类 号：R5[医药卫生—内科学]