脂类及脂蛋白在胃肠道癌患者中的作用  

Role of lipid and lipoprotein in gastrointestinal tract cancer patients

作　　者：周建明[1] 黄波[2] 俸家富[3] 

机构地区：[1]西昌市凉山州第二人民医院检验科,四川西昌615000 [2]自贡市第三人民医院检验科,四川自贡643020 [3]绵阳市中心医院检验科,四川绵阳621000

出　　处：《现代医药卫生》2006年第5期645-646,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨脂质(甘油三酯、总胆固醇)和脂蛋白(高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)在癌形成中的作用。方法:测定56例癌症患者和27例健康对照血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和脂质过氧化终末产物丙二醛(MDA,以此作为脂质过氧化程度标志)浓度。结果:癌症患者TG、TC、LDL-C明显高于对照组,P值均<0.01,同时伴HDL-C(P=0.000)下降。但胃癌患者HDL-C(P=0.085)和结肠癌患者TG(P=0.655)与健康对照无差异。脂质过氧化产物MDA癌症组明显高于对照组(P=0.000),且各癌肿均比对照组高。结论:脂质和脂蛋白可能在癌症形成过程中起着重要作用。Objective：To study the role of lipid（triglyceride and total cholesterol） and lipoprotcin（high-density lipoprotein cholesterol and low-density lipoprotein cholesterol） in gastrointestinal tract cancer patients. Methods：The serum triglyceride （TG）,total cholesterol （TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C） and lipid peroxidation end-product malondialdehyde（MDA, as a marker of lipid peroxidation degree） were measured in 56 gastrointestinal tract cancer patients and 27 healthy controis. Results：Compared to the healthy controls,the serum TC,TG and LDL-C in cancer group were higher （all P〈0.01） while HDL-C decreased （P=0.000）.L/pid peroxidation end-product MDA was found to be significantly elevated in all cancer patients compared with that in the healthy contrels（P=0.000）, but HDL-C in the gastric cancer patients（P=0.085） and TG in the colonic cancer patients（P=0.655） were no significant difference as the date were analysed by ANOVA. Conclusion：The results suggest that lipid and/or lipoprotein may play important role in carcinogenesis.

关 键 词：癌症 脂质过氧化 血液 

分 类 号：R446[医药卫生—诊断学]