进化策略的一种改进及其在蛋白质结构预测中的应用  

An improved evolution strategies and its application to protein structure prediction

作　　者：张红娟[1] 李斌[1] 唐焕文[1] 郭崇慧[1] 

机构地区：[1]大连理工大学应用数学系,辽宁大连116024

出　　处：《计算机与应用化学》2005年第12期1097-1100,共4页Computers and Applied Chemistry

基　　金：国家自然科学基金资助项目(90103033)

摘　　要：进化策略算法是一种模拟自然界生物进化过程的全局优化方法。本文将一种改进的进化策略算法应用于蛋白质三维 HPNX非格模型,较成功地预测了蛋白质序列1RPB、1BPI和1UBQ的折叠趋势,说明了三维HPNX非格模型比简化HP非格模型更能准确地描述蛋白质的折叠情况,同时表明了进化策略算法用于蛋白质结构预测问题是可行的、有效的。Evolution strategies as global optimization search methods, are computing models simulating the evolutionary mechanisms of nature. An improved evolution strategy is applied to protein 3-dimension HPNX off-lattice model, and we successfully predict the structuros of several protein sequences, such as 1RPB,1BPI and 1UBQ. These results show that HPNX off-lattice model is more accurate than HP off-lattice model in representing the folding trends of proteins and evolution strategies are feasible and effective to the prediction of protein structures.

关 键 词：进化策略 HPNX非格模型 蛋白质折叠 

分 类 号：Q71[生物学—分子生物学]