CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles  

作　　者：Wei DENG Ye Feng WANG Chen ZHANG Lei LIU Qing Xiang GUO 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei 230026

出　　处：《Chinese Chemical Letters》2006年第3期313-316,共4页中国化学快报（英文版）

摘　　要：Ma＇s CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1,4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma＇s original methods.Ma＇s CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1,4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma＇s original methods.

关 键 词：Cross coupling reaction CUI N-ARYLATION nitrogen heterocycle proline. 

分 类 号：O626[理学—有机化学] O621.251[理学—化学]