HHV6和HHV7感染与类风湿性关节炎的相关性  

RELATIONSHIP BETWEEN HHV6 AND HHV7 INFECTION AND RHEUMATOID ARTHRITIS

作　　者：王笑峰[1] 孙迎娟[2] 罗兵[1] 李慧[2] 王云[1] 

机构地区：[1]青岛大学医学院微生物学教研室,山东青岛266021 [2]青岛大学医学院附属医院检验科,山东青岛266021

出　　处：《青岛大学医学院学报》2006年第1期53-55,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科技局资助项目(2001KNS-2E-27-1)

摘　　要：目的探讨人疱疹病毒6型(HHV6)和7型(HHV7)感染在类风湿性关节炎(RA)病因学中作用。方法用巢式PCR技术,检测62例类风湿性关节炎病人和138例健康献血员外周血单个核细胞(PBMCs)和血浆中HHV6和HHV7 DNA。结果类风湿性关节炎病人组PBMCs中HHV6和HHV7 DNA阳性率与正常对照组比较均无显著性差异(P>0.05);部分类风湿性关节炎病人血浆中可检出HHV6和HHV7 DNA,而对照组血浆中则为阴性。结论类风湿性关节炎病人中可能存在HHV6或HHV7的活动性感染,与类风湿性关节炎的发生发展有一定关系。Objective To investigate the role of human herpesvirus 6 and 7 （HHV6, HHV7） infection in the etiology of rheumatoid arthritis （RA）. Methods HHV6 and HHV7 DNA from the plasma and peripheral blood mononuclear cells （PBMCs） were tested with nested PCR in 62 RA patients and 138 matched healthy adult donors. Results The differences of positive rates of HHV6 DNA and HHV7 DNA in PBMCs of the patients were not significant compared with those of the healthy controls （P〉0.05） ; HHV6 and HHV7 ; DNA were detected in the plasma of some patients but negative in the plasma of the controls. Conclusion HHV6 and HHV7 DNA are present in the plasma of some RA patients, which suggests that the active in fection of HHV6 and HHV7 may he related to the pathogenesis of RA.

关 键 词：关节炎 类风湿 疱疹病毒6型 人 疱疹病毒7型 人 巢式聚合酶链反应 

分 类 号：R593.22[医药卫生—内科学]