HIV病毒抑制剂中间体5-戊基间苯二酚的合成  

Synthesis of HIV Inhibitor Intermediate 5-Pentyl Resorcinol

作　　者：徐宇伦[1] 张龙[1] 金鑫 宋义新 

机构地区：[1]长春工业大学化工学院,吉林长春130012 [2]大连兆科生化有限公司,辽宁大连116620

出　　处：《精细化工中间体》2006年第1期27-29,共3页Fine Chemical Intermediates

摘　　要：以3,5-二甲氧基苯甲酸为起始原料,与LiH在室温下反应5h生成苯甲酸盐,生成的盐再与正丁基锂进行酰化反应得到3,5-二甲氧基苯戊酮,进而在210℃以下进行乌尔夫-黄鸣龙反应将酮还原,生成3,5-二甲氧基戊苯,所得产物与吡啶盐酸盐熔融,于200℃回流2h,脱甲基制得5-戊基间苯二酚,总收率达60.9%,纯度≥98%。3,5-Dimethoxybenzoic acid reacts with lithium hydride to form salt which is acylated by n-butyllithium to synthesize 1-（3,5-dimethoxyphenyl）-1-pentanone, and then this ketone is reduced by Wolff L-Huangminglong reaction under 210 ℃ to form 3,5-dimethoxy-1-phenylbenzene that refluxs with pyridine and concentrated hydrochloric acid for 2 h at 200℃ to prepare 5-pentyl resorcinol. The total yield of 5-pentyl resorcinol is up to 60.9% and its purity is no less than 98%.

关 键 词：3 5-二甲氧基苯甲酸 酰化 乌尔夫-黄鸣龙还原 5-戊基间苯二酚 

分 类 号：TQ243.11[化学工程—有机化工]