脑络通对麻醉犬脑血流量的影响  

Effects of Naoluotong on Dogs' Cerebral Blood Flow

作　　者：王宇红[1] 陈安[2] 韩炯[1] 余祎[2] 

机构地区：[1]湖南中医学院附属第一医院,长沙市410007 [2]湖南中医学院,长沙市410007

出　　处：《中国药房》2006年第5期338-341,共4页China Pharmacy

摘　　要：目的研究脑络通对麻醉犬脑血流量的影响。方法将麻醉犬随机分为脑络通高、中、低剂量组和阳性对照药桂利嗪、脑血康组及空白对照组,每组6只。给药后不同时间点分别记录、比较颈内动脉血流量、血压、心电图、心率的变化。结果与空白对照组比较,脑络通高、中剂量可显著增加犬脑血流量、降低脑血管阻力,且对动脉血压、心率及心电图无明显影响。结论脑络通具有改善脑血液循环的作用。OBJECTIVE： To observe the effects of naoluotong on dogs＇ cerebral blood flow. METHODS： The anaesthetized dogs were randomly divided into naoluotong （which was subdivided into high, medium and low dose subgroups） group, antigeron positive control group, naoxuekang group, and blank control group with 6 dogs in each group. The internal carotid artery flow （ICAF）, blood pressure （BP）, electrocardiogram （ECG） and heart rates of the dogs were determined at different time after administration with drugs. RESULTS： As compared with the blank control group, the high and medium dose of naoluotong could significantly increase dogs＇ cerebral blood flow and reduce cerebral vascular resistance yet without significant influence on arterial blood pressure, heart rates and ECG. CONCLUSION ： Naoluotong can improve cerebral blood circulation.

关 键 词：脑络通 麻醉 脑血流量 

分 类 号：R285.5[医药卫生—中药学]