慢性乙型肝炎中西医治疗胞溶性与非胞溶性抗病毒效应的研究  

Non-cytolytic antiviral effect and cytolytic inflammatory necrosis in the treatment of hepatitis B by traditional Chinese medical prescription and western medicine

作　　者：邵石祥[1] 耿国钰[1] 郭明芳[1] 李树娟[1] 宋海燕[1] 蔡莉芬[1] 陈勇良[1] 陈秀丽[1] 王瑞敏[1] 

机构地区：[1]河北省石家庄市第五医院,050021

出　　处：《河北医药》2006年第2期86-87,共2页Hebei Medical Journal

摘　　要：目的研究中药和拉米呋啶治疗慢性乙型肝炎患者的抗病毒效应。方法应用中药对37例慢性乙型肝炎患者进行3-6个月连续治疗，并随访观察6-9个月；与34例同期应用拉米呋啶治疗1年的慢性乙型肝炎患者进行对照。治疗前后分别检测肝功能、HBV-M、TNF-α、IFN-γ、IL-12。结果中药治疗组的HBVDNA阴转率为29．73％，拉米呋啶治疗组为79．41％；中药治疗组的HBeAg阴转率、HBeAg／抗HBe转换率为24．32％、21．62％，拉米呋啶治疗组的分别为2．90％、0％。两组治疗后的TNF-α水平均有所降低（P〉0．05）；中药治疗组治疗后的IFN-γ、IL-12水平较拉米呋啶治疗组明显升高（P〈0．05）。结论中药治疗慢性乙型肝炎疗效肯定，在HBeAg阴转、HBeAg／HBeAb转阴方面优于拉米呋啶，能够有效激活慢性乙型肝炎患者的非胞溶性抗病毒效应。Objective To investigate the antiviral effect of traditional Chinese medicine and Lamivudine in the treatment of chronic hepatitis B. Methods A compound traditional Chinese medicine was used in the treatment of 37 chronic hepatitis B patients for 3 - 6 consecutive months, and the patients were further followed up for 6 ~ 9 months.The liver function,HBV-M,TNF-α, IFN-γ,IL-12 were examined before and after treatment, and the result of the examinations were compared with those of 34 chronic hepatitis B patients simultaneously treated with Larnivudine for 1 year as control. Results HBV DNA negative conversion rate in traditional Chinese medicine group was 29.73 % and 79.94% in Lamifvudine group; HBeAg negative conversion rate and HBeAg/Anti-HBe antibody conversion rate were 24.32% and 21.62% respectively, however, which were 2.90% and 0% in Lamivudine group. The levels of TNF：α decreased in beth groups （ P 〉0.05） and the levels of IFN-γ and IL-12 increased significantly in the traditional Chinese medicine group, as compared with Lamivudine group （ P 〈 0.05）. Conclusion The traditional Chinese medicine is effective in treating chronic hepatitis B and HBeAg negative conversion rate and HBeAg/Anti-HBe antibody conversion rate are higher than those of Lamivudine.

关 键 词：慢性乙型肝炎 非胞溶性抗病毒效应 胞溶性炎症坏死 

分 类 号：R512.62[医药卫生—内科学] R978.7[医药卫生—临床医学]