Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates  

作　　者：葛泽梅 李勤 郑少君 程铁明 崔育新 李润涛 

机构地区：[1]School of Pharmaceutical Sciences, Peking University, Beijing 100083, China

出　　处：《Chinese Journal of Chemistry》2006年第3期381-385,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20172006 and 20472008）.

摘　　要：Ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3-bromo-2-oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically （IR, ^1H NMR, ^13C NMR, EI-MS） and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.Ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3-bromo-2-oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically （IR, ^1H NMR, ^13C NMR, EI-MS） and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.

关 键 词：ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylate primary amine ethyl 3-bromo-2-oxopropanoate one-pot synthesis anhydrous potassium phosphate 

分 类 号：O626.2[理学—有机化学]