谷氨酰胺双肽对严重烧伤患者T淋巴细胞亚群的影响  

Effects of Glutamine Dipeptide on T-lymphocyte Subgroups in Severely Burned Patients

作　　者：卢才教[1] 杨宁[1] 章圣辉[2] 张鹏[1] 林才[1] 徐建军[1] 

机构地区：[1]浙江温州医学院附属第一医院烧伤科,温州325014 [2]浙江温州医学院附属第一医院科研所

出　　处：《中国临床营养杂志》2006年第1期15-17,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的观察添加谷氨酰胺双肽的肠外营养对严重烧伤患者T淋巴细胞亚群的影响。方法28例烧伤总面积60.7%±10.0%,深Ⅱ度、Ⅲ度烧伤面积32.1%±4.6%的患者随机分为对照组和实验组,每组14例,两组患者均接受等氮等热卡的肠外营养一周,实验组同时给予谷氨酰胺双肽0.5g.kg-1.d-1。检测入院时(伤后第1天)、用药前(伤后第3天)、用药后(伤后第11天)外周血CD3、CD4、CD8、CD4/CD8。结果伤后第11天,实验组CD4(37.24%±6.34%)和CD4/CD8(1.72%±0.23%)水平均显著高于对照组(分别为25.34%±7.17%和1.02%±0.21%,P<0.05)。结论含谷氨酰胺双肽的肠外营养影响T淋巴细胞亚群的变化,可改善严重烧伤患者的免疫功能。Objective To evaluate the effects of parenteral nutrition supplemented with glutamine dipeptide on T-lymphocyte subgroups in severely burned patients. Methods Twenty-eight severely burned patients were randomly divided into control group （n = 14） and glutamine dipeptide group （GD group, n = 14）. All patients received same nitrogen and calorie for one week. Patients in the GD group were additionally supplemented with glutamine dipeptide （0.5g·kg^-1·d^-1）. Blood samples were obtained for measurement of CD3 , CD4, CD8, and CD4/CD8 on day 1, 3, and 11 after burn. Results On the day 11 after bum, the CD4 （37.24% ± 6.34%） and CD4/CD8 levels （1.72% ± 0.23%） in GD group were significantly higher than CD4 （25.34% ± 7.17% ） and CD4/CD8 （ 1.02% ± 0.21% ） in control group. Conclusion Parenteral nutrition supplemented with glutamine dipeptide may affect T-lymphocyte subgroups and improve the immune function of severely burned patients.

关 键 词：肠外营养 谷氨酰胺双肽 严重烧伤 T淋巴细胞亚群 

分 类 号：R644[医药卫生—外科学]