中国内地汉族系统性红斑狼疮与HLA-DQA1基因关联研究Meta分析  

Meta-analysis of the association between systemic lupus erythematosus with HLA-DQA1 in the Han nationality of Chinese in the mainland of China

作　　者：潘正论[1] 张源潮[1] 孙红胜[1] 

机构地区：[1]山东大学山东省立医院风湿免疫科,济南250021

出　　处：《中华风湿病学杂志》2006年第2期77-81,共5页Chinese Journal of Rheumatology

摘　　要：目的探讨中国内地汉族人群系统性红斑狼疮(SLE)与HLA-DQA1基因的关联情况。方法检索已发表的有关中国内地汉族人群SLE和HLA-DQAl关联研究的文献,剔除不符合要求的文献,应用REVMAN4.1软件进行一致性检验和数据合并。结果研究文献质量可靠,7项研究共纳入447例SLE患者和503例正常对照,中国内地人群SLE的保护基因有HLA-DQA1*0301、P=0.00007,OR=0.64(0.52,0.80)。结论Meta分析明确了中国内地人群SLE的易感基因和保护基因,能够有效解决国人基因关联研究样本偏小所致的研究结论不一致。Objective To explore the association between sysetemie lupus erythematosus （SLE） with HLA-DQA1 in the mainland of China. Method The reported articles about SLE in mainland of China and HLA-DQAl were searched and the meta-analysis via Rev man4.1 was performed. Result Seven studies enrolled 447 SLE patients and 503 controls, HLA-DOA1＊0301 might be of protective value, P=0.000 07, OR=0.64 （0.52, 0.80）. Conclusion Meta-analysis is an importmant method to determine the controversial results of gene association studies performed in the performed in the mainland of China with small sample size.

关 键 词：红斑狼疮 系统性 HLA-DQ抗原 META分析 关联 

分 类 号：R593.241[医药卫生—内科学]