雌激素受体在发育不同时期大鼠大脑的表达  

EXPRESSION CHANGES OF ESTROGEN RECEPTOR IN RAT BRAIN OF DIFFERENT AGES

作　　者：许耘[1] 刘胜洪[2] 王小丽[2] 唐立华[2] 王芳[2] 

机构地区：[1]北京大学基础医学院组织学与胚胎学教研室,北京100083 [2]华中科技大学同济医学院组织学与胚胎学教研室,武汉430030

出　　处：《解剖学报》2006年第1期106-109,共4页Acta Anatomica Sinica

摘　　要：目的探讨雌激素受体(ER)在大鼠大脑神经元及神经胶质细胞表达的增龄性变化。方法采用免疫组织化学方法观察不同年龄正常组及脑损伤组SD大鼠脑内ER的表达变化并行统计学分析。结果正常老年组海马齿状回神经元ER表达明显少于青年组;脑损伤组海马各区出现大量ER阳性反应的胶质细胞,且青年组阳性胶质细胞明显多于老年组。结论老年组海马齿状回神经元雌激素受体表达下降,从而更易发生退行性变;在受到伤害性刺激时青年组胶质细胞表达更多的雌激素受体,从而更好地利用雌激素的神经保护作用。Objective To investigate the estrogen receptor expression character on neurons and glial cells of rat at different ages. Methods Brain sections from normal and injured rats of different ages were chosen to observe the ER immunohistochemistry reaction in cerebrum. Results To compare with normal young rat group, the neurons in hippocampos dentate gyrus of normal aged rat group expressed much less estrogen receptors. There were many ER-positive glial cells appearing in hippocampos of brain injured was rat group, and the positive strain of young injured was much stronger than that of aged rat group. Conclusion The decrease of ER on neurons in dentate gyrus makes the aged more apt to neurodegeneration. The young rats may better utilize the neuroprotection of estrogen against injuries by increasing the amount of ER on glial cells.

关 键 词：雌激素 受体 神经元 胶质细胞 年龄 免疫组织化学 大鼠 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]