琥乙红霉素与7,7,8,8-四氰基对二次甲基苯醌的荷移反应  

The charge transfer reaction between erythromycin ethylsuccinate and 7,7,8,8-tetracyanoquinodemethane

作　　者：李俊[1] 李全民[2] 王新明[1] 

机构地区：[1]中国科学院广州地球化学研究所 [2]河南师范大学化学与环境科学学院,新乡453002

出　　处：《药物分析杂志》2006年第2期225-227,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：广东省自然科学基金团队项目(20003046)

摘　　要：目的:测定琥乙红霉素片剂中琥乙红霉素的含量,增加质量控制和保证手段。方法:利用琥乙红霉素与7,7,8,8-四氰基对二次甲基苯醌(TCNQ)形成1:1荷移络合物,应用分光光度法测定片剂中琥乙红霉素含量。结果:络合物的最大吸收波长是845nm,表观摩尔吸光系数ε为6.01×10~3L·mol^(-1)·cm^(-1),琥乙红霉素在25.86～689.7mg·L^(-1)范围内符合比尔定律,方法的相对标准偏差为0.83%(n=10)。对形成荷移络合物的机理进行了探讨,平均回收率为101%(RSD<1%)。结论:方法简单、灵敏、准确,可作为该药的含量测定方法。Objective： To determine erythromycin ethylsuccinate in tablets and provide the quality control and assurance. Method： A spectrophotometric method based on the charge transfer reaction between 7,7,8,8 -tetracya- noquinodemethane （TCNQ）and erythromycin ethylsuccinate. Results： The molar absorptivity of the complex at 845 nm was 6. 01 × 10^3 L· mol^-1 · cm^-1. Beer＇ s law was obeyed in the range of 25.86 -689.7 mg · L^-1 of erythromycin ethylsuccinate. The relative standard deviation was 0. 83% （ n = 10 ）. The composition of the complex was found to be 1：1 by slope ratio and Job＇s methods. The mechanism of reaction was investigated, and the average recovery was found to be 101% （RSD 〈 1% ）. Conclusion： The method is simple, quick and accurate for the determination of erythromycin ethylsuccinate in tablets.

关 键 词：琥乙红霉素 荷移反应 分光光度法 7 7 8 8-四氰基对二次甲基苯醌(TCNQ) 

分 类 号：R917[医药卫生—药物分析学]