慢性乙型肝炎病毒感染者前C区变异及HBV DNA载量的临床意义  

Clinical significance of HBV precore mutation and the quantities of HBV DNA in chronic hepatitis B virus infection

作　　者：曲俊彦[1] 游晶[1] 唐宝璋[1] 

机构地区：[1]昆明医学院第一附属医院感染科,650032

出　　处：《国际流行病学传染病学杂志》2006年第1期23-24,27,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：目的探讨慢性HBV感染者前C区A1896变异及HBVDNA载量与肝炎病情进展的关系。方法检测116例慢性HBV感染者前C区A1896变异,比较不同临床类型前C区A1896变异阳性率,再根据前C区变异不同,比较不同临床类型HBVDNA含量的差异。结果不同临床类型前C区变异株检出率差异无统计学意义(χ2=2.863,P=0.581)。在慢性HBV携带者中,变异阳性率同时伴有较高水平的HBVDNA量(P=0.003),其余各临床类型均未见明显差异;但变异情况相同的条件下,HBVDNA载量似随着病情的加重呈降低趋势。结论影响肝炎病情进展的因素错综复杂,前C区A1896变异可能不起作用,但前C区A1896变异可能是影响HBVDNA复制的一个因素。Objective To explore the clinical significance of HBV precore mutation and the quantities of HBV DNA in chronic hepatitis B virus infection. Methods HBV precore 1 896 mutation was detected in 116 patients with chronic HBV infection and the positive rates of precore mutation in different clinical groups were compared, and then the quantities of HBV DNA in different clinical groups were distinguished based on the same precore mutation. Results The positive rates of precore mutation in different clinical groups were no discrepancy （X^2 = 2. 863, P=0. 581 ）. The chronic HBV carriers of positive precore mutation had higher HBV DNA（ P = 0.003） and there were no discrepancy in other groups. But it was possible that the quantities of HBV DNA decreased following the pathological prognosis in the same precore mutation. Conclusions Many factors can infect the pathological prognosis of HBV infection, it is possible that precore mutation is not one of those, but precore mutation may infect the replication of HBV DNA.

关 键 词：乙型肝炎病毒 前C区 变异 HBV DNA 

分 类 号：R512.62[医药卫生—内科学]