检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:崔速南[1] 汪明明[1] 李新立[1] 杨公炜[1] 张秀珍[1] 杜文军[1]
出 处:《国际流行病学传染病学杂志》2006年第1期25-27,共3页International Journal of Epidemiology and Infectious Disease
摘 要:目的探讨结缔组织生长因子(CTGF)的肝内表达与肝硬化的关系。方法对93例慢性乙型肝炎和肝硬化患者的肝组织活检样本,采用免疫组化方法进行CTGF肝内表达研究,结合HE染色和网状纤维染色,分析比较慢性乙型肝炎和肝硬化的CTGF肝内表达及表达的细胞定位。结果肝硬化患者CTGF的表达强度明显高于慢性乙型肝炎患者(P<0.01),肝纤维化程度越高,CTGF表达越强烈。CTGF的表达与慢性乙型肝炎的炎性活动程度明显相关(P<0.05)。CTGF的表达主要集中于汇管区和纤维化区,肝星形细胞、成纤维细胞和窦状隙内皮细胞染色常呈阳性。结论CTGF的表达与肝纤维化及肝硬化程度密切相关,肝星形细胞、成纤维细胞和窦状隙内皮细胞是肝内CTGF的重要来源。Objective In order to explore the relationship between intrahepatic express of connective tissue growth factor(CTGF) and liver fibrosis or cirrhosis due to hepatitis B virus infection. Methods 93 samples of liver biopsies of chronic hepatitis B (CHB) and cirrhosis was enrolled in the study. Intrahepafic express of CTGFF was assayed by immunohistocbemical staining. Results Express of CTGF in cirrhosis was significantly stronger than in CHB ( P 〈 0.01 ), and was correlated with inflammation of hepatic tissue( P 〈 0.05). Express of CTGF was observed in portal tracts and fibrous septa predominantly in the fibrogenesis areas. The positive staining was observed in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts. Conclusions Intrahepatic express of CTGF has an important rule in pathogenesis of fibrosis or cirrhosis. Hepatic stellate cells, sinusoidal endothelial cells and fibroblasts seem to be the major cellular sources of CTGF in the liver.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.117