病毒感染与自身免疫性糖尿病  

Viral infection and autoimmune diabetes

作　　者：裴紫燕 张立煌[1] 

机构地区：[1]浙江大学免疫学研究所,杭州310031

出　　处：《国际流行病学传染病学杂志》2006年第1期71-72,F0003,共3页International Journal of Epidemiology and Infectious Disease

基　　金：国家973计划(2003CB515503)

摘　　要：目前认为,1型糖尿病(T1D)是T细胞介导的自身免疫性疾病,以遗传为基础,在某些环境因素的作用下,诱发以胰岛炎为病理特征的胰岛β细胞自身免疫反应,损伤β细胞使其丧失合成和分泌胰岛素的功能,引起糖代谢紊乱。病毒感染是其中的一个重要因素。文中综述多种病毒感染与T1D的关系,着重讨论病毒介导的自身免疫性糖尿病的发病机制以及病毒感染对糖尿病的作用。T1D is an autoimmune disease characterized by T-cell mediated autoimmune destruction of pancreatic β-cells. It＇ s pathogeny is probably due to a combination of genetic and environmental factors and genetic factors play a major role in this process. This β-cell specific autoimmunity characterized by insulitis destroies the β-cells and makes the β-eells lose the function of synthesis and secretion of insulin, results in the turbulence of sugar metabolism. Viral infection is one of the major risk factors. In this review the relationships between viral infections and T1D are discussed detailedly, with emphasis on the patbogenesis of the virus-mediated autoimmune diabetes and the prevention of autoimmune diabetes by virus infection.

关 键 词：病毒 1型糖尿病 自身免疫 

分 类 号：R587.1[医药卫生—内分泌] R542.2[医药卫生—内科学]