不同人群感染丙型及庚型肝炎病毒危险性分析  

Risk of hepatitis C and G infection in different populations

作　　者：洪楷[1] 丁映淑 陈林兴[1] 邱杰文[1] 

机构地区：[1]汕头大学医学院第二附属医院检验科,广东汕头515041 [2]广东省南澳县妇幼保健院妇产科

出　　处：《中国公共卫生》2006年第3期346-347,共2页Chinese Journal of Public Health

摘　　要：目的研究不同人群感染丙型肝炎病毒(HCV)及庚型肝炎病毒(HGV)的危险性并探讨其传播途径。方法采集不同人群的血清,运用酶联免疫吸附试验(ELISA)及荧光定量聚合酶链式反应(FQ-PCR)检测抗-HCV、抗-HGV及HCV-RNA、HGV-RNA。结果一般人群、医护人员、普通孕妇、乙型肝炎病人、血液透析(HD)病人抗-HCV的阳性率分别为0.89%(58/6468),2.93%(5/171),0.93%(17/1836),11.5%(47/410)和51.4%(54/105),抗-HGV的阳性率为0.6%(3/500),0(0/171),2.5%(6/240),9.3%(13/140)和14.3%(5/105);母婴传播率HCV为16.7%;HGV为25%。血液透析(HD)病人有无输血史HCV感染率差异有统计学意义(χ2=7.72,P<0.01)。结论有血液暴露史者是HCV及HGV感染的高危人群;血液及母婴传播是重要的传播途径。Objective To investigate the HCV and HGV infection rate from the different populations and its route of transmission. Methods Serum samples from the different populations were tested for anti - HCV and anti - HGV by ELISA. HCV- RNA and HGV- RNA was detected by FQ - PCR. Results Anti - HCV positive rates for general crowd, clinical medical workers, pregnant women, hepatitis B patients and blood donors were 0.89 %, 2.93 %, 0.93 %, 11.5 % and 51.4 %. Anti - HGV positive rates were 0.6 %, 0, 2.5 %, 9.3 % and 14.3 %. the rates of mother - to - infant transmission of HCV and HGV were 16.7 % and 25 %. The Anti - HCV positive rates for blood transfusion and no blood transfusion had extremely significant differenees（X^2 = 7.72, P〈0.01 ）. Conclusion The high risk people of hepatitis C and G infection was blood transfusion. Mother - to - infant transmission and blood transfusion were major way of HCV and HGV infection.

关 键 词：丙型肝炎 庚型肝炎 血液暴露 母婴传播 输血 

分 类 号：R512.63[医药卫生—内科学]