间二苄胍衍生物的合成  

Synthesis of Phenylenedimethylene Bis(guanidiniums) Derivatives

作　　者：宋伟[1] 陆晓峰[1] 陆国元[1] 

机构地区：[1]南京大学化学系配位化学国家重点实验室,南京210093

出　　处：《高等学校化学学报》2006年第3期460-463,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20372032)资助.

摘　　要：通过间二苄氯衍生物和二甲酰胺钠的亲核取代及水解方便地制备了相应的间二苄胺.后者与甲基异硫脲作用生成间二苄胍硫酸盐,经离子交换得到相应的间二苄胍盐酸盐.Naturally occurring and synthetic compounds containing guanidine display a wide range of biological activities and are used as a receptor for organic anions. This paper reports the synthesis of phenylenedimethy-lene diamines and bis （guanidiniums） derivatives. The phenylenedimethylene diamine derivatives were prepared by the reaction of phenvlenedimethvlene dichloride with sodium diformamide and then hvdrolvzing with hydrochloric acid/ethanol solution. The diamines were respectively treated with S-methyl/sothiourea sulfate to give the corresponding phenylenedimethylene bis （guanidiniums） sulfate, and then they were converted to the corresponding chlorides by ion-exchange process.^1I H NMR spectra and ESIMS data indicate that they display a stronger interaction with organic anions.

关 键 词：弧 双胍 二胺 合成 

分 类 号：O626[理学—有机化学]