反复自然流产患者主动免疫治疗前后免疫功能的变化  

Analysis the changes of immunologic function in patients with recurrent spontaneous abortion after active immunotherapy

作　　者：王鸣[1] 林萍[1] 孟庆勇[1] 胡振兴[1] 

机构地区：[1]江苏省徐州市妇幼保健院生殖内分泌科,徐州221009

出　　处：《中华当代医学》2006年第1期12-13,共2页Chinese Modern Medicine

摘　　要：目的探讨反复自然流产患者主动免疫治疗前后免疫功能的变化及临床效果。方法采用自身对照的方法，对95例确诊为母胎免疫低下型反复自然流产的患者，采用配偶白细胞进行主动免疫治疗4—6个疗程。观察治疗前后的免疫功能的变化以及再次妊娠情况。结果95例患者主动免疫治疗后再次妊娠成功84例，成功率迭88．4％（84／95），失败11例，失败率为11．6％（11／95）。抗配偶CD3、CD4、CD8（％）均有不同程度的提高，分别由治疗前的-1．71±1．54、-1．87±1．17、-1．61±1．03，上升为治疗后的1．20±1．32、1．42±1．41、1.29±0．89，与治疗前相比差异有显著性（P〈0.05）。结论采用主动免疫的治疗方法，对母胎免疫低下型RSA患者，能改善免疫功能，诱导母体对胚胎的免疫耐受，有效的挺高妊娠盛功率．Objective To investigate the clinical efficacy and the change of immunologic function after the active immunotherapy in RSA patients. Methods The changes of immunologic function and the subsequent pregnancies of 95 cases with RSA of materal alloimmunization deficiency were observed after 4 - 6 courseso of active immunotherapy with white blood cell of the partner by auto control method. Results After active immunitherapy, the subsquent pregnanies rate of all patients was 88.4% （84/95） ; the failure rate was 11.6% （ 11/95 ）. The antibody to partners of CD3 %. CD4%. CD8 % was increased significantly （ P 〈0.05） ,from-1.71±1. 54、-1. 87±1.17、-1.61±1.03 to 1.20±1.32、1.42±1.41、1.29±0.89 than before. Conclusion To RSA of materal alloimmunization deficiency, active immunization treatment could improve immunity and induce maternal immunological tolerance, os that the success rate of pregnancy could be increased effectively.

关 键 词：反复自然流产 主动免疫 免疫功能 

分 类 号：R714.21[医药卫生—妇产科学] R749.3[医药卫生—临床医学]