盐酸纳洛酮对急性重型脑外伤的疗效观察  

Clinical Effects of Hydrochloride Naloxone in the Treatment of Acute Severe Traumatic Brain Iinjury

作　　者：冯桥显[1] 杨玉焕[2] 张艳杰[1] 郭付有[1] 宋来君[3] 游潮[1] 

机构地区：[1]四川大学华西医院神经外科,四川成都610041 [2]东南大学医院,江苏南京210096 [3]郑州大学第一附属医院神经外科,河南郑州450052

出　　处：《华西医学》2006年第1期4-5,共2页West China Medical Journal

摘　　要：目的:探讨盐酸纳洛酮对急性重型脑外伤的临床疗效。方法:120例急性重型脑外伤病人随机分为盐酸纳洛酮治疗组(以下简称治疗组)62例和对照组58例,观察并比较病人的颅内压(ICP)和GCS评分,同时比较伤后6个月时病人的神经功能恢复情况。结果:治疗组ICP低于照组(P<0·05);GCS评分治疗组优于对照组(P<0·05);6个月后神经功能恢复优于对照组(P<0·05)。结论:盐酸纳洛酮可降低急性重型脑外伤病人ICP增高的幅度,缩短昏迷时间,促进病人神经功能的恢复,改善预后。Objective： To asses the clinical effects of hydroctdoride naloxone in treatment of acute severe brain injury. Methods： One- hundred and twenty patients with severe brain injury （GCS3 - 8） were randomly divided into two groups： there were 62 patients treated with hydrochloride naloxone in the treatment group and 58 patients treated on routine in the control group. ICP, GCS and long - term effects of the two groups were compared. Results： ICP in the treatment group was lower than that of the contral group （ P 〈 0.01 ）. GCS in the treatment group was significantly better than that of the control group （ P 〈 0.05）. Long - term effects of the treatment group were better than those of the control group. Conclusions： Hydrochloride naloxon could lower ICP, improved the recovery from coma and reduced the motality as well as the disability in patients with acute severe brain injuries.

关 键 词：纳洛酮 脑外伤 颅内压 神经功能 

分 类 号：R651.15[医药卫生—外科学]