常通口服液中大黄酸的高效毛细管电泳测定  

Determination of Chrysophanic Acid in Changtong Oral Solution by HPCE

作　　者：郭丹[1] 陈娜娜[2] 杨西晓[1] 侯连兵[1] 

机构地区：[1]第一军医大学南方医院药学部 [2]第一军医大学药物研究所,广东广州510515

出　　处：《中国医药工业杂志》2006年第3期194-195,共2页Chinese Journal of Pharmaceuticals

基　　金：国家新药研究基金资助项目(96-901-05-245)

摘　　要：建立了高效毛细管电泳法测定常通口服液中的大黄酸。采用毛细管柱,运行缓冲液为30mmol/L硼砂溶液(pH8.2),检测波长254nm。大黄酸在3.2～19.2μg/ml浓度范围内线性关系良好,平均回收率97.8%,RSD为1.28%。A HPcE method for determination of chrysophanic acid in Changtong oral solution was established. A capillary column was used with 30mmol/L borate buffer solution （pH 8.2） as the electrophoretic buffer solution, at the detection wavelength of 254 nm. The calibration curve was linear in the range of 3.2 - 19.2μg/ml. The average recovery was 97.8% withRSDof 1.28%.

关 键 词：大黄酸 常通口服液 高效毛细管电泳 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]