N-(2-羧基-1,3,4-噻二唑-5-基)-N'-芳酰基硫脲与芳氧乙酰基硫脲的合成与生物活性  

Synthesis and Biological Activity of N-(2-Carboxyl-1,3,4-thiadiazol-5-yl)-N'-aroyl Thioureas and Aryloxyacetyl Thioureas

作　　者：龚银香[1] 王子云[2] 张正文[3] 陈传兵[3] 汪焱钢[3] 

机构地区：[1]长江大学化学与环境工程学院,荆州434000 [2]周口师范学院化学系,周口466000 [3]华中师范大学化学学院,武汉430079

出　　处：《有机化学》2006年第3期360-363,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20072009)资助项目.

摘　　要：为了寻找高活性的杂环农药,用5-氨基-1,3,4-噻二唑-2-羧酸与芳酰基异硫氰酸酯及芳氧乙酰基异硫氰酸酯反应,合成出18种新的芳酰基硫脲与芳氧乙酰基硫脲,采用红外光谱、核磁共振氢谱和元素分析证明了其结构,初步的生物活性测定试验表明,部分目标化合物具有良好的植物生长调节活性,其中2c,2d,3b和3g具有良好的生长素活性.In order to find high biological active pesticide, eighteen novel aroyl thioureas and aryloxyacetyl ones have been synthesized by the reaction of 5-amino-1,3,4-thiadiazol-2-carboxylic acid with aroyl isothiocyanates and aryloxyacetyl isothiocyanates, with their structure confirmed by IR, ^1H NMR spectra and elemental analysis. The preliminary biological activity tests showed that some title compounds have good activity as plant growth regulator, and 2c, 2d, 3b and 3g have fine activity of auxin.

关 键 词：芳酰基硫脲 芳氧乙酰基硫脲 合成 生物活性 生长素 

分 类 号：TQ450.1[化学工程—农药化工]