5-(色酮-3-亚甲基)-3-芳基硫乙内酰脲的合成  

Synthesis of 5-(Chromon-3-ylmethylidene)-3-arylthiohydantoin

作　　者：惠永海[1] 曹玲华[1] 

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046

出　　处：《有机化学》2006年第3期391-395,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.29962002;20462006)资助项目.

摘　　要：以α-氨基乙酸和芳基异硫氰酸酯为起始原料制备3-芳基-2-硫乙内酰脲,然后在酸性条件下与3-甲酰基色酮发生类Knoevenagel缩合反应,合成得到了16种新的5-(色酮-3-亚甲基)-3-芳基硫乙内酰脲类化合物.所有化合物的结构均经IR,1HNMR,LC-MS和元素分析确证,并做了初步的生理活性测试.Sixteen novel 5-chromon-3-ylthiohydantoins were synthesized by quasi-Knoevenagel condensation of 3-aryl-2-thiohydantoins, obtained from glycine and aryl isothiocyanetes, with 3-formylchromones in the presence of acid. Their structures were confirmed by IR, ^1H NMR, LC-MS spectra and elemental analyses. Biological activity has been elementarily evaluated.

关 键 词：硫乙内酰脲 3-甲酰基色酮 合成 

分 类 号：TQ247[化学工程—有机化工]