磺脲类药物继发性失效患者短期胰岛素泵强化治疗的临床观察  

Intensive therapy of continuous subcutaneous insulin infusion on diabetics with secondary sulfonylurea failure

作　　者：龙菊华[1] 盛杰[1] 周谊辉[1] 

机构地区：[1]中南大学湘雅医院内分泌科,湖南长沙410008

出　　处：《中国现代医学杂志》2006年第5期763-764,共2页China Journal of Modern Medicine

摘　　要：目的观察胰岛素泵(胰岛素皮下连续脉冲式输注,CSII)对磺脲类药物继发性失效的2型糖尿病患者强化治疗的效果。方法将78例磺脲类药物继发性失效的2型糖尿病患者随机分为常规多次皮下注射(MSII)组(42例)和CSII组(36例)进行强化胰岛素治疗。结果CSII组患者血糖达标时间,平均住院的天数和胰岛素的用量明显少于MSII组;CSII组的血糖波动幅度较MSII组明显降低。低血糖的发生风险在两组患者间差异没有显著性。结论对于磺脲类药物继发性失效的2型糖尿病患者,CSII强化治疗较MSII治疗具有更多的优点,可能是最合适的胰岛素治疗方案。[Objective] To investigate the effect of intensive therapy of continuous subcutaneous insulin infusion （CSII） on Type 2 Diabetes Mellitus patients with Secondary Sulfonylurea Failure. [Methods] 78 patients were randomly divided into MSII group （42 cases） and CSII （multiple subcutaneous insulin injection） group （36 cases）. [Resuits] The time when the goal of blood glucose control was arrived and the mean days of hospitalization,in CSII group was shortcr than that in, MSII group,and the total insulin administration dose in CSII group was lower than that in MSII group; fluctuation argument of blood glucose was decreasing in CSII group; the rate of hypoglycemia in tow groups was no diffc,cnce. [Conclusions] For Type 2 Diabetes Mellitus patients with Secondary Sulfonylurea Failure ,CSII is better than MSII. CSII raay be an ideal method of insulin therapy in these patients

关 键 词：胰岛素泵 多次皮下注射 糖尿病 磺脲类药物 继发性失效 

分 类 号：R587.1[医药卫生—内分泌]