消旋卡多曲在空气中的热分解动力学  

Kinetics of Thermal Decomposition of Racecadotril in Air

作　　者：陶友田[1] 占丹[1] 张克立[1,2] 

机构地区：[1]武汉大学化学与分子科学学院 [2]武汉大学纳米科学和技术研究中心武汉430072

出　　处：《化学学报》2006年第5期435-438,共4页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20071026)资助项目.

摘　　要：用热分析(TG/DTA/DSC)技术研究了消旋卡多曲(C21H21NO4S)在空气中的热分解过程.热分析结果表明,消旋卡多曲在空气中一步分解,其熔点为77.4℃.用Friedman法,Flynn-Wall-Ozawa(FWO)法和ASTME698法求取了分解过程的活化能E,并通过多元线性回归法给出了可能的机理函数.The thermal decomposition processes taking place in the solid-state racecadotril have been studied in air using TG-DTG/DTA and DSC techniques. TG-DTG/DTA and DSC curves showed that the decomposition proceeded through a well-defined step in air with the melting point of 77.4 ℃. The activation energies were calculated through the Friedman, Flynn-Wall-Ozawa and ASTM E698 methods, and the possible conversion functions were estimated through the multiple-linear regression method.

关 键 词：消旋卡多曲 TG/DTG/DTA 差示扫描量热 热分解 动力学 

分 类 号：TQ460.1[化学工程—制药化工]