扶正护脑胶囊对脑出血大鼠心肌组织中TXB_2/6-Keto-PGF_(1α)的影响  

The Effect of Fuzhenghunao Capsule(扶正护脑胶囊 ) on TXB_2 and 6- Keto- PGF_(1α) of Myocardium in Rats with Intracerebral Hemorrhage

作　　者：赵彦青[1] 孙塑伦 高颖[1] 王硕仁[1] 朱陵群[1] 张壮[1] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]国家中医药管理局,北京100026

出　　处：《中国中医急症》2006年第3期281-282,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金课题(No.01LP06)

摘　　要：目的研究扶正护脑胶囊对脑出血大鼠心肌组织中TXB2和6-Keto-PGF1α含量的影响及其作用机制。方法60只动物随机分为假手术组、模型组、扶正护脑组和安宫牛黄组,分别于术后6、24、72h3个时相点取材,采用放免的方法检测心肌组织中TXB2和6-Keto-PGF1α的含量并观察其T/K比值的变化。结果模型组心肌TXB2含量显著增加,两个治疗组心肌TXB2含量均显著减少,术后6、24h安宫牛黄组降低TXB2的幅度大于扶正护脑组,术后72二者无显著性差异;模型组心肌6-Keto-PGF1α含量轻度增加,两个治疗组心肌6-Keto-PGF1α含量均有下降趋势,但无统计学意义;模型组心肌T/K比值显著增加,两个治疗组均显著降低,术后6、24h安宫牛黄组降低情况优于扶正护脑组,术后72h二者无显著差异。结论TXB2/6-Keto-PGF1α的比例失调是脑出血后心肌损伤的主要病理机制之一,扶正护脑胶囊能纠正T/K的失衡状态。Objective:To observe the effect of Fuzhenghunao Capsule(扶 正 护 脑 胶 囊 ) on TXB2 and 6- Keto- PGF1α in rats with intracerebral hemorrhage and explore the mechanism. Methods:60 rats were randomly divided into 4 groups:the sham,the model,the fuzhenghunao and the angongniuhuang.The content of TXB2 and 6- keto- PGF1α were tested by radioimmunoassay at 6h,24h and 72h after operation.Results:The data of TXB2 and T/K were obviously increased in the sham group,and they were decreased in the two treatment groups.The effect of the angongniuhuang group was better than that of the fuzhenghunao group at 6h and 24h.But there were no difference between two groups at 72h.The data of 6- keto- PGF1α was slightly increased in the model group,and compared with the two treatment groups,They were showed no difference.Conclusion:The imbalance of T/K play an important role in cerebral- cardiac syndrome,Fuzhenghunao Capsule could correct the disorderly condition.

关 键 词：扶正护脑胶囊 血栓素B2 6-酮-前列环素F1Α 

分 类 号：R285.5[医药卫生—中药学] R542.2[医药卫生—中医学]