慢性低氧性肺动脉高压大鼠体内血管活性物质表达的变化及意义  

Expressions of ANP and CGRP in plasma of rats with chronic hypoxic pulmonary hypertension and their clinical significance

作　　者：彭利静[1] 李志超[1] 李伟[2] 李志斌[1] 闫志强[1] 张齐[1] 刘毅[1] 罗颖[1] 

机构地区：[1]第四军医大学基础部病理生理学教研室,陕西西安710033 [2]解放军第451医院医务处,陕西西安710054

出　　处：《第四军医大学学报》2006年第5期431-433,共3页Journal of the Fourth Military Medical University

摘　　要：目的:观察慢性低氧性肺动脉高压(HPH)大鼠血浆中心房钠尿肽(ANP)和降钙素基因相关肽(CGRP)的表达变化.方法:用低压、低氧的方法复制大鼠慢性HPH模型,放射免疫法检测血浆中血管活性物质ANP和CGRP表达的变化.结果:慢性HPH大鼠血浆中血管活性物质ANP和CGRP的表达均发生了变化,呈现先降低后增高的表现,即低氧3wk>正常>低氧2wk.结论:在慢性HPH形成过程中,随着肺小动脉壁的增厚,血浆中血管活性物质ANP和CGRP的表达先降低后增高.其变化可能与慢性HPH过程中肺动脉压升高和肺小动脉壁的结构重建有一定关系.AIM： To observe the expression of such vasoactive peptides as atrial natriuretic peptide （ANP） and calcitonin generelated peptide （CGRP） in the plasma of rats with chronic hypoxic pulmonary hypertension （ HPH ）. METHODS ： Twelve chronic HPH rat models were established in low-pressure and hypoxic conditions and divided evenly into 2 groups： hypoxic 2-week group and hypoxic 3-week group. Another 6 rats as control group were fed under normal pressure and normoxia conditions. The expressions of ANP and CGRP in the plasma of HPH rats were detected by radio y （RIA） method. RESULTS： RIA results showed that compared with the concentrations of ANP and CGRP in plasma of control group, the concentrations of ANP and CGRP in plasma of hypoxic 2-week group decreased while those of hypoxic 3-week group increased. The tendency was hypoxic 3-week group 〉 control group 〉 hypoxic 2-week group. Compared with those in hypoxic 2-week group, the expressions of ANP and CGRP were higher in hypoxic 3-week group （P 〈 0.05）. CONCLUSION： In the process of chronic HPH, the expressions of ANP and CGRP in plasma decrease first and then increase. ANP and CGRP may play a regulative role in pulmonary hypertension and pulmonary arterial reconstruction in chronic HPH rats. There is a correlation between the low-pressure and hypoxia induced HPH and the increased ANP and CGRP in rats.

关 键 词：低氧 肺动脉 平滑肌 心房钠尿肽 降钙素基因相关肽 大鼠 

分 类 号：R541.9[医药卫生—心血管疾病]