Intestinal Behcet's disease with pyoderma gangrenosum:A case report  

作　　者：ToshioNakamura KiyotakaKurachi ShohachiSuzuki HiroyukiKonno Hiroaki Yagi 

机构地区：[1]Second Department of Surgery Hamamatsu UniversiW School of Medicine, Hamamatsu 431-3192,Japan [2]Department of Dermatology,Hamamatsu University School of Medicine. Hamamatsu 431-3192,Japan

出　　处：《World Journal of Gastroenterology》2006年第6期979-981,共3页世界胃肠病学杂志（英文版）

摘　　要：We report here a very rare case of intestinal Behcet＇s disease with pyoderma gangrenosum. A 16-year-old woman who was diagnosed with intestinal Behcet＇s disease by the presence of cutaneous pathergy together with two major criteria （oral and genital aphthoses） and one minor criterion （gastrointestinal manifestations）, was referred to our hospital with a left lower leg ulcer and abdominal pain in September 1989. Colonoscopy demonstrated flare-up colitis involving the entire colon. Her lower leg lesion was a painful destructive ulcer with an irregular margin and a ragged overhanging edge. Based on these clinical and laboratory findings, we diagnosed her cutaneous ulcer as pyoderma gangrenosum developing with exacerbated intestinal Behcet＇s disease. Her cutaneous and intestinal lesions were poorly controlled though she received oral prednisolone treatment for a month. Because of aggravated abdominal symptoms with peritoneal irritation, we performed total colectomy in November 1989. The resected specimen was histologically compatible with intestinal Behcet＇ s disease showing severe inflammation with deep ulcerations and neutrophil accumulation. Subsequently, pyoderma gangrenosum rapidly improved. This clinical course may suggest the close relationship between pyoderma gangrenosum and intestinal Behcet＇s disease.我们这里与脓皮病 gangrenosum 报导肠的 Behcet 的疾病的一个很稀罕的案例。被皮肤的过应性的存在和二个主要标准(口头、生殖器的 aphthoses ) 和一个次要的标准(胃肠的表明) 与肠的 Behcet 的疾病诊断的一个 16 岁的女人，被指我们有左的医院在 1989 年 9 月降低腿溃疡和腹的疼痛。结肠镜检查表明了包含全部冒号的骤发大肠炎。她的更低的腿损害是有不规则的边缘和一个破旧悬于边的痛苦的破坏溃疡。基于这些临床并且实验室调查结果，我们作为与加重的肠的 Behcet 的疾病发展的脓皮病 gangrenosum 诊断了她的皮肤的溃疡。尽管她接受了口头的氢化尼松处理一个月，她的皮肤、肠的损害糟糕被控制。因为有腹激怒的加重的腹的症状，我们在 1989 年 11 月执行了全部的结肠切除术。resected 标本与肠的 Behcet 与深溃疡和嗜中性的累积显示出严重发炎的疾病组织学地兼容。随后，脓皮病 gangrenosum 很快改善了。这堂临床的功课可以建议在脓皮病 gangrenosum 和肠的 Behcet 的疾病之间的靠近的关系。

关 键 词：Behcet＇s disease Pyoderma gangrenosum 

分 类 号：R597[医药卫生—内科学]