槐胺碱对小鼠免疫功能的影响  

Effect of Sophoramine on Immune Function of Mice

作　　者：张佩[1] 李淑华[1] 金英[2] 金丽杰 

机构地区：[1]锦州医学院微生物教研室,121001 [2]锦州医学院药理教研室 [3]锦州市第二医院药局

出　　处：《中草药》1996年第1期25-27,共3页Chinese Traditional and Herbal Drugs

摘　　要：观察了槐胺碱（SA）对正常小鼠免疫功能的影响。结果表明：SA15、20mg／kg减低胸腺重量，降低E花环形成率，抑制T淋巴细胞转化，但对脾脏重量无明显影响，也不影响脾脏溶血空斑形成。SA25mg／kg则显著降低胸腺和脾脏重量，降低E花环形成率，抑制T淋巴细胞转化。而各剂量SA均不影响腹腔巨噬细胞吞噬功能。The effects of sophoramine (SA) on immune system in normal mice were studied. SA 15. 20mg/kg reduced the weight of thymus,decreased the rate of E rosette,and also suppressed T lymphocyte transformation. The weight and the hemolytic plaque of spleen were not influenced by SA at 15. 20mg/kg. At the dose of 25mg/kg,SA reduced the weight of thymus and spleen,decreased the rate of E rosette and suppressed the T lymphocyte transformation. All of the doses of SA didn' t affect the phagocytotic function of peritoneal macrophage.

关 键 词：槐胺碱 淋巴细胞转化 免疫功能 

分 类 号：R285.5[医药卫生—中药学]