胎盘生长因子及受体在妊娠肝内胆汁淤积症患者胎盘中的表达及其意义  

Expression and significance of placenta growth factor and its receptor in placenta for patients with intrahepatic cholestasis of pregnancy.

作　　者：秦惠芬[1] 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《中国优生与遗传杂志》2006年第3期33-35,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨胎盘生长因子(PLGF)及受体(F lt-1)在妊娠肝内胆汁淤积症患者胎盘中的表达及其意义。方法采用免疫组织化学方法测定30例妊娠肝内胆汁淤积症患者(ICP组)和30例正常晚期妊娠妇女(对照组)的胎盘组织及8例早孕绒毛组织中PLGF及F lt-1的表达。同时还用抗FⅧRA抗体标记ICP组和对照组孕妇胎盘中的血管密度。结果PLGF及F lt-1在早孕绒毛中主要分布于滋养叶细胞,在ICP患者和对照组胎盘中分布基本一致,主要分布于合体滋养细胞、细胞滋养细胞、血管内皮细胞和绒毛间质细胞。在ICP胎盘中PLGF、F lt-1表达强度及胎盘血管密度均明显低于对照组(P<0.01)。相关分析显示,胎盘组织中PLGF表达强度与胎盘血管密度呈正相关。结论妊娠肝内胆汁淤积症患者胎盘PLGF及F lt-1表达下降与胎盘滋养叶细胞侵入异常、胎盘血管形成异常、胎盘血管密度降低有关,可能是ICP胎儿妊娠结局不良的原因。Objective： To find out the expression and significance of placenta growth factor （PLGF） and its receptor （Flt - 1 ） in placenta for patients with intrahepatic cholestasis of pregnancy （ICP）. Methods： The expression of PLGF and its receptor in placentas from 30 ICP patients （ICP group）, placentas from 30 normal third trimester pregnant women （normal group） and fetal villi from 8 first trimester pregnant women were detected by immunohistochemistry. The placental vascular density of ICP group and normal group was also determined by immunohistochemical FⅧ RA staining. Results： PLGF and its receptor Flt - 1 mainly distribute in trophocytes in the fetal villi of first trimester. The distribution of which in placenta was found in villous trophoblast, placental blood vessels and villous stroma in ICP group and normal group. But both the level of PLGF and its receptor Flt - 1 and the placental vascular densities were significantly lower in ICP group than that in normal group （ P 〈 0. 01 ）. Furthermore, there was positive correlation between the expression of PLGF and the count of vessels in placentas. Conclusion： The lower expression of PLGF and its receptor Flt - 1 in placenta from ICP patients is related to the abnormal invasions of trophoblast, the inadequate blood vessel formation and the decrease of placental vascular density, which could lead to fetal unhealthy pregnancy outcome.

关 键 词：胎盘生长因子 受体 胎盘 妊娠并发症 胆汁淤积 肝内 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]