11例男性染色体异常核型与病因分析  

Analysis on abnormal karyotypes and pathogeny in 11 male patients.

作　　者：苏爱[1] 王振华[1] 刘金成[1] 王修海[1] 纪静[1] 

机构地区：[1]青岛大学医学院生物学教研室,266021

出　　处：《中国优生与遗传杂志》2006年第3期52-53,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的应用细胞遗传学检查,对有流产史、发育迟缓的男性患者病因进行分析,探讨对生殖的影响。方法采用外周血染色体G显带技术,对男性患者进行细胞遗传学检测。结果发现异常核型11例,其中染色体易位6例、2例47,XXY、3例大Y染色体。结论男性染色体核型异常是导致流产和发育迟缓的重要因素。Objective： Pathogeny of male patients who had the symptoms of spontaneous abortion, growth retardation is analyzed with eytogenetics in order to investigate the effect of male reproduction. Mothods： Male patients＇ eytogeneties analysis is carried out with peripheral blood chromosome G banding methods. Results： According to the patients＇ cytogeneties examination, it is found there are 11 cases abnormal chromosomal karyotypes, including 6 cases of chromosome translocation, 2 eases of 47, XXY, 3 cases of big Y chromosome. Conclusion： Chromosome karyotypes abnormalities play an important role in male patients of spontaneous and growth retardation.

关 键 词：易位 染色体 流产 

分 类 号：R698[医药卫生—泌尿科学]