血管内皮生长因子与血管细胞粘附分子在妊高征发病中的作用  

Effecf of pathogenesis on the VEGM and VCAM-1 in PIH.

作　　者：杨宗利[1] 王福玲[1] 刘佩秋[1] 相尧美[1] 丁钰[1] 

机构地区：[1]青岛大学医学院附属医院妇产科,266003

出　　处：《中国优生与遗传杂志》2006年第3期69-70,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血管内皮生长因子及血管细胞粘附分子-1在妊高征发病中的作用。方法选取49例妊高征妇女(其中轻度15例、中度16例及重度18例),35例正常晚期妊娠妇女为研究对象,采用ELISA方法测定其血精VEGF、VCAM-1的水平。结果妊高征组血清VEGF浓度明显低于正常妊娠组(P<0.01).而VCAM-1浓度则明显高于正常妊娠组(P<0.01),轻度妊高征组血清VEGF、VCAM-1浓度与正常妊娠组无明显差别(P>0.05),中、重度妊高征组血清VEGF浓度明显低于正常妊娠组(P<0.01).而血清VCAM-1浓度明显高于正常妊娠组(P<0.01)。结论血清VEGF浓度的降低可能与胎盘浅着床有关,血清VCAM-1的升高参与了妊高征血管内皮损伤过程,VEGF、VCAM-1均可能与妊高征的发病机制有关。Objective： To find out the role of vascular endothelial growth factor and vascular cell adhesion molecule - 1 in the genesis of pregnancy - induced hypertension （PIH）. Methods ： 49 women with PIH （ including 15 women with mild PIH, 16women with moderate PIH, 18 women, with severe PIH）, 35normal pregnant women were investigated. Serum levels of VEGF and VCAM - 1 were measured by ELISA. Results ： Serum levels of VEGF wet lower in PIH group than that in normal pregnant group, while the levels of VCAM - 1 were higher than that in normal group. There is no difference between the serum levels of VEGF. VCAM - 1 in mild PIH and those in normal pregnancy. VEGF levels in moderate and severe PIH were significantly lower than that in normal pregnancy, while VCAM - 1 levels were higher. Conclusion： The reduced serum levels of VEGF may relate with superficial implantation. The increased VCAM - 1 levels may participate in the process of vascular endothelium damages in PIH. VEGF and VCAM - 1 may play a role in the genesis of PIH.

关 键 词：血管内皮生长因子 血管细胞粘附分子 妊高征 

分 类 号：R714.246[医药卫生—妇产科学]