新生儿缺氧缺血性脑损伤血胃泌素水平动态变化的临床意义  

Clinical significance of dynamical changes of the blood GAS levels in neonates with HIBD.

作　　者：朱薇薇[1] 王学燕[2] 吴蕾[2] 王莹[1] 

机构地区：[1]山东大学医学院.济南市中心医院 [2]济南市中心医院儿科,山东济南250013

出　　处：《中国优生与遗传杂志》2006年第3期89-90,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨新生儿缺氧缺血性脑损伤（HIBD）与血清胃泌素（GAS）异常分泌的关系及其水平变化的临床意义。方法应用放射免疫分析法（RIA）测定67例窒息新生儿（包括45例HIBD患儿和22例无HIBD患儿）病程2d内、3—5d、7—10d、12—15d血GAS含量，并对其数据进行统计学分析。结果HIBD患儿在整个病程中血GAS水平均有明显升高。非HIBD组血GAS与对照组比较无统计学意义。结论HIBD可引起GAS分泌异常，其水平与病程成反比。Objective： To explore the relationship between the HIBD of newborn and abnormal secretion of plasma gastrin, and explore the clinical significance of the changes of the blood GAS level. Methods： Serum gastfin concentration was measured by radioimmmunoassay in 67 newborns with asphyxia （include 45 newborns with HIBD and 22 newborns without HIBD） in the 2, 3 -5, 7 - 10, and 12 - 15 day of the course of disease, and did statistical analysis. Results： The blood GAS concentration of neonatal HIBD increased dramatically during the whole course of the disease. The blood GAS concentration of newborns with no HIBD has no statistical significance compared to the normal control group. Conclusion： The HIBD of newborn can cause abnormal secretion of plasma gastfin and there were negative correlation between serum gastrin levels and the course of disease.

关 键 词：足月儿 窒息 缺氧缺血性脑损伤 胃泌素 

分 类 号：R722.1[医药卫生—儿科]