经皮吸收促进剂的研究与应用进展  

Research and application of penetration enhancers

作　　者：王文刚[1] 恽榴红[1] 王睿[2] 周筱青[2] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]解放军总医院临床药理研究室,北京100853

出　　处：《中国新药杂志》2006年第4期254-261,共8页Chinese Journal of New Drugs

摘　　要：透皮给药系统作为最成功的非口服控释给药系统之一,可有效避免肝脏首过效应和胃肠道药物降解、调控释药速率及血药浓度、降低服药频率和不良反应、提高患者顺应性。经皮吸收促进剂在透皮给药系统研究中起着重要作用。现就其应用与联用、选择与评价、促透机制研究及其对水溶性和大分子药物的促透作用等方面,对近年来的研究进展进行综述。Transdermal drug delivery system （TDDS） has emerged as one of the most successful non-oral controlled release systems. Major advantages of TDDS include avoidance of drug degradation in hepatic and gastrointestinal, predetermined release rate and blood drug level, less frequent dosage regimen and side effects, and increased patient compliance. Penetration enhancers （PE） play an important role in the TDDS. This review presented the applications and mechanism of PE regarding to delivering macromolecules and hydrophilic drugs across the skin. Optimization and evaluation of single and combined PE were also discussed.

关 键 词：透皮给药系统 经皮吸收促进剂 促透剂协同联用 

分 类 号：R944.9[医药卫生—药剂学]