西那沙星对幼龄大鼠的软骨毒性  

Chondrotoxicity of sinafloxacin in immature rats

作　　者：栗志远[1] 陆国才[1] 袁伯俊[1] 姜华[1] 戴益民[1] 佘佳红[1] 黄矛[1] 

机构地区：[1]第二军医大学新药评价中心,上海200433

出　　处：《中国新药杂志》2006年第4期274-276,共3页Chinese Journal of New Drugs

摘　　要：目的:观察西那沙星(sinafloxacin)静脉注射对幼龄大鼠关节软骨的影响。方法:40只大鼠,雌雄各半,按照体重随机分为西那沙星低、高剂量组(iv,10和60 mg·kg^(-1))、加替沙星阳性对照组(iv,60 mg·kg^(-1))和空白对照组(iv生理氯化钠溶液10 mL·kg^(-1))。各组连续给药7 d。d7给药后24 h处死动物取完整膝、髋关节进行病理组织学检查。结果:西那沙星可使幼龄大鼠膝、髋关节软骨表层幼稚软骨细胞数量减少,骨骺软骨细胞变性坏死,且存在量效关系。结论:西那沙星10～60 mg·kg^(-1)连续iv 7 d对幼龄大鼠关节软骨有破坏作用。Objective. To evaluate the effects of sinafloxacin on joint cartilage in immature rats. Methods ： Forty 3-week old rats with a male to female ratio of 1：1 were randomly assigned to four intravenous injection groups： sinafloxaein 10 or 60 mg· kg^-1, gatifloxaein 60 mg·kg^-1 or saline solution alone 10 mL·kg^-1 for 7 d, respectively. The rats were euthanazed in 24 hours after the 7-day administration of drugs to collect the knees and hip joints including osteoepiphysis cartilages for histopathologieal examination. Results： The quantity of naive chondrocytes in the surface layer of knees and hip joints were decreased in the dose-dependent manner. Dose-related degeneration and necrosis of epiphyseal ehondrocytes in both knees and hip joints were found. Conclusion： Sinafloxaein is chondrotoxic to immature rats.

关 键 词：西那沙星 幼龄大鼠 软骨毒性 

分 类 号：R965.3[医药卫生—药理学] R978.19[医药卫生—药学]