大鼠外侧隔核注射精氨加压素的心血管效应(英文)  

Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

作　　者：高列[1] 蒋乃昌[1] 罗庆华[1] 朱筑霞[1] 

机构地区：[1]贵阳医学院生理教研室

出　　处：《中国药理学报》1996年第1期49-52,共4页Acta Pharmacologica Sinica

摘　　要：目的:研究精氨加压素(Arg)在外侧隔核对心血管活动的影响。方法:用乌拉坦麻醉大鼠,在外侧隔核注入Arg,记录平均动脉血压和心率变化。结果:Arg(100,200和400ng)使平均动脉血压分别升高0.9±0.6,2.3±1.3和4.0±1.4kPa;心率分别加快12±27,50±33,和89±27bpm。用 d(CH_2)_5Tyr(Me)Arg预先阻断外侧隔核的V1型受体,可完全消除Arg在该核团的心血管效应。用酚妥拉明预先阻断外周α受体,可完全消除Arg在外铡隔核的升压效应,但不影响其加快心率效应。结论:Arg可作用于外侧隔核的V1型受体,发挥对心血管活动的中枢控制作用。AIM: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). METHODS: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. RESULTS: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0. 9±0. 6, 2. 3±1.3, 4. 0±1. 4 kPa, respectively) maximal changes of HR were 12 ±27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreat-ment of the LSN with a vasopressin 1 type antagonist d(CH2)5Tyr(Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral a-adrenergic blockade with phento-lamine blocked the hypertension responses to injection of Arg into the LSN. CONCLUSION: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediates by stimulation of sympathetic outflow.

关 键 词：精氨加压素 隔核 血压 心率 中枢神经 大鼠 

分 类 号：R964[医药卫生—药理学] R972.5[医药卫生—药学]