菌蚀型生物降解材料的合成与表征  

The Synthesis and Characterization of the Bacterial-Erodible Biodegradable Materials

作　　者：陈建海[1] 陈清元[1] 沈家瑞[2] 

机构地区：[1]广州第一军医大学南方医院药学部,广州510515 [2]华南理工大学高分子材料系,广州510640

出　　处：《北京生物医学工程》2006年第1期16-19,共4页Beijing Biomedical Engineering

基　　金：国家自然基金(39970876)资助

摘　　要：本文力图设计与合成在人体结肠厌氧菌存在环境下,可被微生物降解的生物材料。用三种亲疏水性不同、软硬段不同的三种单体,即甲基丙烯酸羟乙酯(HEMA)、甲基丙烯酸(MAA)、甲基丙烯酸甲酯(MMA)为载体,并用对甲基丙烯酰胺偶氮苯(BMAAB)为偶联剂,合成了聚甲基丙烯酸羟乙酯-甲基丙烯酸甲酯-甲基丙烯酸[P(HEMA-MMA-MAA)]三元偶氮聚合物。用红外、紫外、核磁共振进行化学结构表征,并测定了该材料的溶胀性能,比较了聚合物降解前后分子量、热性能与形态变化。结果证明材料的降解程度与材料中亲水组分含量直接相关。To design and synthsizc the micmbiogenic degradable biomaterials under the colonic environment in human body. The azocopolymer poly （HEMA-MMA-MAA） was synthesized using three kinds of monomers, 2-hydroxycthylmethacrylato （HEMA）, methylmethacrylato （MMA）, and methacrylic acid （MAA）,as comonomers azobisisobutyronitfile （AIBN） as initiator, cross-linked with Bis （methacryloylamino） - azabenzcne （BMAAB）. The chemical structure of azocopolymar was elucidated with UV, FTIR spectroscopy and nuclear magnetic resonance data. The swelling behavior was evaluated by the swelling equilibrium parameter Q. The biedcgradation properties were assessed using Differential Scanning Calorimeters （DSC） and Gel Permeation Chromatography （GPC）. The surface morphology of the material before and after degradation was observed by Scanning Electron Microscopy （SEM）. The investigated results show that the degradation behavior of this azopolymer was relevant to the ratio of three components in the copolymcrs.

关 键 词：生物可降解聚合物 偶氮聚合物 溶胀性 生物降解 

分 类 号：R318.08[医药卫生—生物医学工程]