阿司匹林与硝苯地平单用和合用对麻醉犬血液动力学的影响  

Effects of aspirin and nifedipine alone or in com- bination on hemodynamics in anesthetized dogs

作　　者：宋益民[1] 李增晞[1] 石山[1] 

机构地区：[1]包头医学院心血管研究室

出　　处：《中国药理学报》1996年第1期72-74,共3页Acta Pharmacologica Sinica

基　　金：Project supported by the National Natural Science Foundation of China;№ 38960058.

摘　　要：目的:研究阿司匹林(Asp)与硝苯地平(Nif)并用对麻醉犬血液动力学的影响。方法:TTI,LVWI,MAP,TPVR,FBF,LVSP,dp/dt_(max),LVEDP,HR,均同步记录于多道生理记录仪及电磁流量计上。结果:Asp5,10mg·kg^(-1)iv对 麻醉犬血液动力学各项指标均无明显影响。Nif15μg·kg^(-1) iv可使TTI,MAP,TPVR显著下降,FBF明显提高,对LVSP,dp/dt_(max),HR,CI无明显影响。Asp 5mg·kg^(-1)与Nif 15μg·kg^(-1)并用与Nif单用结果相似。结论:Asp不影响Nif改善心血管功能的作用。AIM: To study the effects of the combination of aspirin (Asp ) and nifedipine (Nif) on hemodynamics in 8 anesthetized dogs. METHODS: Tension time index (TTI), left ventricular work index (LVWI), mean arterial pressure (MAP), and total peripheral vascular resistance (TPVR), femoral artery blood flow (FBF), ventricular systolic pressure (LVSP), maximum of its first derivative (dp/dtmax), left ventricular end dias-tolic pressure (LVEDP) and heart rate (HR) were recorded on polygraph and electromagnetic flowmeter. RESULTS: Asp 5, 10 mg·kg-1, iv exerted a significant effect on the hemodynamic indices, wheras Nif 15 μg · kg-1, iv decreased TTI, LVWI, MAP, and TRVR, increased FBF distinctively, and slightly affected LVSP, dp/ dtmax LVEDP, and HR. The effects of Asp in combination with Nif on hemodynamics were similar to those of Nif alone. CONCLUSION: The improvement of cardiovascular function caused by Nif was not affected by the presence of Asp.

关 键 词：阿司匹林 硝苯地平 血流动力学 药物相互作用 

分 类 号：R972[医药卫生—药品] R542.22[医药卫生—药学]